Saturday, June 22, 2002

Registration 3:00 - 6:00 p.m. South Loggia, East Breakers
*If you plan to attend the ASN Final Banquet on Wednesday evening, June 26 - please pick-up your entrance ticket at the ASN Registration desk by Monday, noon. If you do not plan to attend the banquet, please notify us at the registration desk.

Opening Reception 6:30 - 8:30 p.m. Ponce de Leon Ballroom I, II, III
(nametag required for entry; drink ticket available in packet)

Sunday, June 23, 2002

*ASN registration desk, located in South Loggia East, is open Sunday, 7:15 a.m. - 1:15 p.m.

*Coffee complimentary of ASN is available in the Ponce de Leon Foyer, 7:30 - 8:30 a.m.*

*All posters beginning with AP should be posted in the Venetian room by 8:15 a.m. today and dismantled by 5:30 p.m., today.

*If you plan to attend the ASN Final Banquet on Wednesday evening, June 26 - please pick-up your entrance ticket at the ASN Registration desk by Monday, noon. If you do not plan to attend the banquet, please notify us at the registration desk.

Opening Remarks 8:15 - 8:30 a.m. Ponce De Leon I, II, III & IV
Robert Yu, President, American Society for Neurochemistry
Douglas Anderson, Chairman, Host Committee

Basic Neurochemistry Lecture
8:30 - 9:30 a.m. Ponce De Leon I, II, III & IV
Introduction by Robert Yu, President, American Society for Neurochemistry

Patricia Goldman-Rakic
FROM BEHAVIOR TO MOLECULE AND BACK: THE CHALLENGE OF NEUROSCIENCE

Symposium 1 9:30 - 11:30 a.m. Ponce De Leon I, II, III (enter left)
REGULATION OF NEURAL DEVELOPMENT BY BMP AND ACTIVIN FAMILY MEMBERS
Organizer: Alison Hall

S01-01 BMP Regulation of Stem Cell Differentiation
Kessler, J.A., Gomes, W., Gutha, U., Israsena, N.

S01-02 Dorsally Derived BMP4 Inhibits The Induction of Spinal Cord Oligodendrocyte Precursors
Miller, R.H., Wang, R.-Z., Geertman, R. , Maier, C.E.

S01-03 Activin and BMPS Regulate Sensory Neuronal Differentiation
Hall, A.K., Dinsio, K.J., Haner, N., Cruise, B.A.

S01-04 Role of Bone Morphogenetic Protein Signaling in Noradrenergic Neuron Development
Rohrer, H., Stanke, M., Schneider, C., Muller, F.,
Howard, M., Vogel-Hopker, A.

Symposium 2 9:30 - 11:30 a.m. Ponce De Leon IV (enter center)
THE GENETIC, MOLECULAR AND CELLULAR BASES OF NEUROFIBROMATOSIS TYPE 1
Organizer: Nancy Ratner

S02-01 A Role of NFI as a Tumor Suppressor
Parada, L.F., Zhu, Y.

S02-02 CNS Glial Progenitors and Schwann Cells in Neurofibromatosis Type 1
Ratner, N., Miller, S.J., Ling, B., Huang, Y.N., Bennett, M.R., McKinnon, R., Rizvi, T.A.

S02-03 RAS Activation is Both Necessary and Sufficient to Promote Perineurial Glial Growth in Drosophila Peripheral Nerves
Stern, M., Fazio, G., Lynn, A., Yager, J.

S02-04 speaker unable to attend, replaced by:
Signaling Pathways in NF1 Associated and Spontaneous Human Astrocytomas
Guha, A.

Symposium 3 9:30 - 11:30 a.m. Ponce de Leon V, VI (enter right)
FUNCTION AND PATHOGENESIS IN PARKINSON'S DISEASE
Organizer: Tamie Chilcote

S03-01 Synuclein: The Third Amyloid in Alzheimer's Disease
Trojanowski, J.Q.

S03-02 Toward a Normal Function For The Synuclein Proteins
George, J.M.

S03-03 Environmental Risk Factors and Parkinson's Disease: The Role of Interactions Between Neurotoxicants and Alpha-Synuclein
Di Monte, D.A.

S03-04 Interaction Between Parkin and Alpha-Synuclein
Shimura, H., Schlossmacher, M., Hattori, N., Mizuno, Y., Kosik, K. , Selkoe, D.

W01-01 Involvement of Multiple Molecular Events in Methamphetamine-Induced Neurodegeneration: Evidence From CDNA Array Analysis
Cadet, J.L.

W01-02 Molecular Mechanism Underlying Neuroprotection by Rasagiline
Naoi, M., Maruyama, W., Youdium, M.B.H.

W01-03 (cancelled)

W01-04 GDNF-Induced Neuroprotection Against Oxidative Stress in Dopaminergic Cells
Zigmond, M.

W01-05 C-DNA Microarray to Determine Molecular Events in Neurodegeneration and Neuroprotection
Youdim, M.B.H., Levites, Y., Weinreb, O., Mandel, S.

Lunch On Your Own 11:30 a.m. - 1:00 p.m.

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Sunday afternoon, June 23, 2002

Poster Presentations/Exhibits 1:00 - 2:30 p.m. Venetian Ballroom

**Please note: The following posters will be grouped and displayed together Sunday and will be located after AP13-02: AP02-05, AP06-02, AP08-02, AP11-01, AP12-07, BP07-09 and W05-05.

AP01-01 Calandria, J.M., Alfonzo, J., Pollevick, G., Casas, O.R., Frasch, C., Idoyaga-Vargas, V.
REGULATION OF GENE EXPRESSION DURING THE DEVELOPMENT OF CORTICO-THALMIC CONNECTION IN RAT

AP01-02 Romm, E., Kim, J.G., Kim, N.W., Nagle, J., Hudson, L.D.
THE MYT1 FAMILY RECRUITS HISTONE DEACETYLASE TO REGULATE NEURAL TRANSCRIPTION

AP01-03 Santos-Berrios, C., Weisman, G.A., Gonazlez, F.A.
P2X7 RECEPTOR INDUCES GENE EXPRESSION

AP01-04 Varela-Nallar, L., Cuitino, L., Sagal, J.P., Inestrosa, N.C.
REGULATION OF PRION PROTEIN GENE EXPRESSION BY HEAVY METALS

AP01-05 Wight, P.A., Li, S., Moore, C.L., Dobretsova, A.
MYELIN PROTEOLIPID PROTEIN (PLP) INTRON 1 DNA IS REQUIRED TO TEMPORALLY REGULATE PLP GENE EXPRESSION IN THE BRAIN

AP02-01 Coggin, M.H., Srapionyan, R.M., Galoyan, A.A., Brecher, A.S.
THE EFFECT OF PROLINE RICH POLYPEPTIDE ON THE INTERACTION BETWEEN ACTIVATED FACTOR X AND ANTI-THROMBIN III

AP02-02 Dawson, R., Dominy, J.
TAURINE-HYPOTAURINE INTERACTIONS IN C6 GLIOMA CELLS

AP02-03 Dyer, C.A., Daikhin, E., Henry, A.
CHANGES IN PHENYLALANINE LEVELS DIFFERENTIALLY ALTER TYROSINE AND DOPAMINE LEVELS IN PKU MOUSE BRAIN STRUCTURES

AP02-04 Pomper, M.G., Musachio, J.L., Zhang, J., Zhou, Y., Scheffel, U., Hilton, J., Maini, A., Wong, D.F., Dannals, R.F., Kozikowski, A.P.
11C-MCG: SYNTHESIS, UPTAKE SELECTIVITY AND PRIMATE PET OF A PROBE FOR GLUTAMATE CARBOXYPEPTIDASE II

**AP02-05 Rojas, C., Frazier, S.T., Flanary, J., Slusher, B.S.
STEADY STATE KINETICS AND INHIBITION OF NAALADASE USING A NEW IN VITRO 96-WELL PLATE ASSAY

AP02-06 Shokati, T., Zwingmann, C., Butterworth, R.F., Leibfritz, D.
MULTINUCLEAR NMR STUDY OF THE REGULATION OF OXIDATIVE METABOLISM BY GLUTAMINE IN CULTURED NEURONS AND ASTROCYTES

AP02-07 Sweatt, A., Wallin, R., Wood, M., LaNour, K.F., Hutson, S.M.
EXPRESSION OF BRANCHED CHAIN TRANSAMINASES IN PERIPHERAL NERVES

AP03-01 Andorn, A.C., Bennett, T.L., Hogan, D., Taglialatella, G.
IRON, HYDROGEN PEROXIDE AND ASCORBATE AS STIMULANTS OF LIPID PEROXIDATION IN BRAIN MEMBRANES

AP03-02 Bieberich, E., MacKinnon, S., Silva, J., Li, D.D., Tencomnao, T., Irwin, L.N., Kapitonov, D., Yu, R.K.
REGULATION OF GANGLIOSIDE BIOSYNTHESIS BY ENZYME COMPLEX FORMATION OF GLYCOSYLTRANSFERASES

AP03-03 Caputto, B.L., Gil, G.A., Portal, M.M., Borioli, G.A., Retner, M.L.,
Guido, M.E.
C-FOS ACTIVATES PHOSPHOLIPID METABOLISM IN EVENTS ASSOCIATED TO GROWTH AND DIFFERENTIATION

AP03-04 Daniotti, J.L., Crespo P., Zurita, A.
EFFECTS OF GANGLIOSIDES ON THE DISTRIBTUION OF A GPI-ANCHORED PROTEIN IN PLASMA MEMBRANE

AP03-05 Cruz, N.F., Dienel, G.
HIGH BRAIN GLYCOGEN LEVELS: LABILITY DURING TISSUE SAMPLING & EXTRACTION

AP03-06 Dawson, G., Kilkum, J.K., Goswami, R.
CERAMIDE GENERATED DURING APOPTOSIS IS LOCALIZED TO DETERGENT-INSOLUABLE FRACTIONS OF THE CELLS (RAFTS)

AP03-07 Deth, R.C., Waly, M.
IGF-1 AND P13-KINASE REGULATE FOLATE-DEPENDENT METHYLATION IN AN ETHANOL-SENSITIVE MANNER

AP03-08 Gasparyan, E.P., Hoveyan, G.A., Amirkhanyan, H.M., Simonyan, M.A., Zakharyan, A.R., Amirkhanyan, L.T., Karageuzyan, K.G.
PECULIARITIES OF LIPID COMPOSITION DISORDERS IN RAT BRAIN AND MYOCARDIUM AT UNILATERAL RIGHT GANGLIONS SYMPATHECTOMY

AP03-09 Hauser, E.C., d'Azzo, A., Seyfried, T.N.
INHERITANCE OF BRAIN BETA-GALACTOSIDASE ACTIVITES AND GANGLIOSIDES IN CROSSES OF DBA/2 AND KNOCKOUT MICE

AP03-10 Hewett, J.A., Vidwans, A.S., Hewett, S.J.
CYCLOOXYGENASE-2 PROTEIN IS CLEAVED FOLLOWING ACTIVATION BY ARACHIDONIC ACID AND ENDOCANNABINOIDS

AP03-11 Murphy, E.J., Cole, N., Glynn, A., Nussbaum, R.L.
BRAIN PHOSPHOLIPID LEVELS AND COMPOSITION ARE ALTERED IN ALPHA-SYNUCLEN GENE-ABATED MICE

AP03-12 Nalivaeva, N.N., Plesneva, S.A., Dubrovskaya, N.M., Zhuravin, I.A.
EFFECT OF GANGLIOSIDES ON ADENYLYL CYCLASE ACTIVITY IN THE CORTEX AND STRIATUM OF RATS

AP03-13 Irwin, L.N., Biebeerich, E., Li, D.D., Silva, J., Yu, R.K.
GENE EXPRESSION FOR GLYCOSYLTRANSFERASES IN TRANSFECTED NEUROBLASTOMA CELLS

AP03-14 Suetake, K., Lious, S.S., Tencomnao, T., Kraemer, S., Yu, R.K.
ANALYSIS OF GLYCOSPHINGOLIPID COMPOSITION OF A NEURAL PROGENITOR CELL LINE

AP03-15 Zeng, G., Gao, L., Xia, T., Tencomnao, T., Yu, R.K.
TRANSCRIPTION FACTORS NF-KB AND SP1 ARE MAJOR DETERMINANTS OF THE BASAL PROMOTER ACTIVITY OF THE RAT GD3-SYNTHASE GENE

AP03-16 O'Banion, M.K., Maida, M.E., Moore, A.H.
INTERLEUKIN-1 INCREASES EXPRESSION OF CYTOSOLIC AND MEMBRANE PGE SYNTHASE IN MOUSE ASTROCYTES AND BRAIN

AP03-17 Rosenberger, T.A., Hovda, J.T., Peters, J.M.
DISRUPTION OF PPAR(BETA), RESULTS IN DISTINCT GENDER DIFFERENCES IN MOUSE BRAIN PHOSPHOLIPID

AP03-18 Saito, Mi., Saito, Ma., Szakall, I., Vadasz, C.
EFFECTS OF ETHANOL ON GANGLIOSIDES IN THE PLASMA, LIVER, AND BRAIN OF INBRED MOUSE STRAINS

AP03-19 Sobocki, T., Sobocka, M.B., Banerjee, P.
PREDICTION, ISOLATION, AND SEQUENCING OF THE PROMOTER FOR HUMAN AMINOPHOSPHOLIPID TRANSLOCASE (APTL) II

AP03-20 Zwingmann, C., Chatauret, N., Liebfritz, D., Butterworth, R.F.
NMR STUDY OF 13C-GLUCOSE AND 13C-ACETATE METABOLISM IN THE BRAIN OF RATS WITH ACUTE LIVER FAILURE

AP04-01 Ahboucha, S., Desjardins, P., Chatauret, N., Butterworth, R.F.
INDUCTION OF "PERIPHERAL-TYPE" BENZODIAZEPINE RECEPTOR EXPRESSION AND NEUROSTEROID PRODUCTION IN BRAIN IN LIVER FAILURE

AP04-02 Leiswitz, A.V., Jung, J.E., Perez-Alzola, P., Fuenzalida, K.M., Inestrosa, N.C., Bronfman, M.
ETHANOL SPECIFICALLY DECREASES PPAR BETA MRNA AND PROTEIN IN B12 OLIGODENDROCYTE-LIKE CELLS

AP04-03 Murphy, P., Sharp, A., Dello Russo, C., Gavrilyuk, V., Feinstein, D.L.
ANSAMYCINS REDUCE NOS2 EXPRESSION AND ATTENUATE EAE IN MICE

AP04-04 Rodriguez de Lores Arnaiz, G., Lopez Ordieres, M.G.
ACUTE HALOPERIDOL ADMINISTRATION TO RATS PREVENTS NEURONAL NA+, K+-ATPASE INHIBITION BY NEUROTENSIN

AP04-05 Hadjiconstantinou, M., Isola, R., Colvin, A., Tejwani, G., Neff, N.H., Duchemin, A-M.
ALTERED DYNORPHIN IN THE STRIATUM AFTER ACUTE NICOTINE OR NICOTINE WITHDRAWAL

AP04-06 McCarthy, M., Hadjiconstantinou, M.
OPIOID RECEPTORS DURING NICOTINE WITHDRAWAL

AP05-01 Kaur, H., Bigbee, J.W.
NOVEL ROLES FOR ACETYLCHOLINESTERASE IN BRAIN TUMORS

AP06-01 Ramos, A.J., Ortiz de Roazs, J.M., Brusco, A., Villar, M.J.
NEURONAL AND GLIAL ALTERATIONS AFTER CORTICAL DEVASCULARIZATION

**AP06-02 Grossfeld, R.M., Engler, J.A., Gottesman, J.M., Harkins, J.C., Urazaev, A.K., Lieberman, E.M.
PROPERTIES OF CRAYFISH GLUTAMINASE AND RELEVANCE TO SYNTHESIS OF THE PUTATIVE AXON-GLIA SIGNALING AGENT NAAG

AP06-03 Quarles, R.H., Dashiell, S.D., Weiss, M.D., Pant, H.C.
SCHWANN CELL TO AXON SIGNALING MEDIATED BY MYELI-ASSOCIATED GLYCOPROTEIN AFFECTS THE STRUCTURE OF MYELINATED AXONS

AP06-04 Gow, A., Southwood, C.M., Scherer, S., Garbern, J., Kamholz, J.
THE NKX6-2 HOMEOPROTEIN REGULATES ASSEMBLY OF HETEROTYPIC CELL ADHESION JUNCTIONS IN THE CNS

AP07-01 Haley, J., Doan, T., Kitano, M.
MYELIN INDUCED ALTERATIONS IN CYCLICAMP IN CULTURED ASTROCYTES

AP07-02 Bal-Price, A., Moneer, Z., Brown, G.C.
NITRIC OXIDE INDUCES RAPID CALCIUM-DEPENDENT RELEASE OF VESICULAR GLUTAMATE FROM ASTROCYTES

AP07-03 Gegg, M., Beltran, B., Bolanos, J.P., Salas-Pino, S., Moncada, S., Clark, J.B., Heales, S.J.R.
THE DIFFERNTIAL EFFECT OF NITRIC OXIDE ON GLUTATHIONE METABOLISM IN ASTROCYTES AND NEURONS

AP07-04 Heales, S.J.R., Stewart, V.C., Lam, A.J., Stone, R., Clark, J.B.
ASTROCYTE DERIVED NITRIC OXIDE AND THE NEURODEGENERATIVE PROCESS. THE ROLE OF GLUTATHIONE AND TETRAHYDROBIOPTERIN

AP07-05 Velazquez, B., Colon, F., Weisman, G.A., Gonazlez, F.A.
ACTIVATION OF P2 NUCLEOTIDE RECEPTORS IN RAT ASTROCYTES

AP07-06 Chorna, N., Erb, L., Weisman, G.A., Gonazlez, F.A.
ROLE OF P2Y2 NUCLEOTIDE AND VITRONECTIN RECEPTORS INTERACTION IN HUMAN 1321N1 ASTROCYTOMA CELLS PROLIFERATION

AP07-07 Lasater, A., Cruz, N.F., Ball, K., Dienel, G.
INFLUENCE OF PLASMA METABOLITES ON CALCULATED [2-14C] ACETATE UTILIZATION IN BRAIN

AP07-08 Rama Rao, K.V., Jayakumar, A.R., Murthy, Ch.R.K., Norenberg, M.D.
ASTROCYTE SWELLING BY AMMONIA: ROLE OF FREE RADICALS AND MITOCHONDRIAL PERMEABILITY TRANSITION

AP07-09 Hernandez-Perez, M.G., Chevres, M., Weisman, G.A., Gonzalez, F.A.
A TRIPLE POINT MUTANT OF THE MURINE P2Y2 RECEPTOR ATTENUATES UTP-0MEDIATD DESENSITIZATION IN 1321N1 CELLS

AP07-10 Dello Russo, C., Galea, E., Gavrilyuk, V., Feinstein, D.L.
THE PPAR-G AGONIST PIOGLITAZONE INCREASES GLUCOSE METABOLISM IN ASTROCYTES

AP07-11 Gavrilyuk, V., Feinstein, D.L.
NOREPINEPHRINE INCREASES INHIBITORY IKBA EXPRESSION IN ASTROCYTES

AP08-01 Utsunomiya, I., Taguchi, K., Ren, J., Usuki, S., Ariga, T., Yu, R.K., Miyatake, T.
PRESYNAPTIC BLOCKADE OF NEUROMUSCULAR TRANSMISSION BY ANIT-GA1 GANGLIOSIDE ANTIBODIES

**AP08-02 Wozniak, K.M., Wu, Y., Calvin, D., Tang, Z., Liu, W., Zhang, W., Sima, A., Slusher, B.S.
N-ACETYLATED-ALPHA-LINKED-ACIDIC-DIPEPTIDASE (GCPII) INHIBITORS AS NOVEL THERAPEUTICS FOR NEUROPATHY

AP08-03 Gow, A., Southwood, C.M., Garbern, J., Jian, W.
THE UNFOLDED PROTEIN RESPONSE IS ACTIVATED IN PELIZAEUS-MERZBACHER DISEASE

AP09-01 Wakade, C., Mahdik, S.P., Terry, A.V., Chiu, F.-C.
ATYPICAL NEUROLEPTICS STIMULATE NEUROGENESIS IN ADULT RAT BRAIN

AP09-02 Yao, J.K., Leonard, S., Reddy, R.D.
REDUCED GLUTATHIONE REDOX STATE IN SCHIZOPHRENIA

AP10-01 Bottigheri, T., Arning, A., Damon, A.
THE EFFECT OF S-ADENOSYLMETHIONINE ON LOCOMOTOR ACTIVITY IN THE RAT

AP10-02 Cheli, V., Adrover, M., Guyot-Revol, V., Blanco, C., Vidal, R., Vazquez, P., Alche, L., Epstein, A., Jerusalinsky, D.
VIRAL VECTORS CARRYING NR1 SEQUENCES INJECTED INTO RAT HIPPOCAMPUS INTERFERED WITH LEARNING AND MEMORY

AP10-03 Perrone-Bizzozero, N., Yang, Y., Merhege, M., Bolognani, F.
MICROARRAY ASSAYS REVEAL DIFFERENTIAL EXPRESSION OF HIPPOCAMPAL AND ANYGDALAL GENES DURING CONTEXTUAL FEAR CONDITIONING

AP10-04 Jerusalinsky, D., Kornisiuk, E., Romanelli Ferreira, A., Sanchez, G., Furstenau, L., Blanco, C., Cervenansky, C., Quillfeldt, J.
M1 AND M4 MUSCARINIC RECEPTORS FROM HIPPOCAMPUS ARE POSITIVELY INVOLVED IN MEMORY CONSOLIDATION

AP10-05 Reis, E.A., Zugno, A.I., Lamers, M.L., Franzon, R., Matte, C., Netto, C.A., Wyse, A.T.S.
VITAMINS E AND C PREVENT THE IMPAIRMENT OF RETENTION OF AN INHIBITORY AVOIDANCE TASK CAUSED BY ARGININE ADMINISTRATION

**AP11-01 Barinka, C., Rinnova, M., Sacha, P., Mlcochova, P., Rojas, C., Majer, P., Slusher, B, Konvalinka, J.
STRUCTURE AND ACTIVITY OF RECOMBINANT HUMAN GLUTAMATE CARBOXYPEPTIDASE II

AP11-02 Choi, I.-Y., Lei H., Gruetter, R.
NEUROTRANSMITTER METABOLISM IN VIVO IN DEEP PENTOBARBITAL ANESTHESIA

AP11-03 Fiszer de Plazas, S., Vacotto, M., Siccolone, G., Flores, V.,
Rodriguez Gll. D.J.
DISTRIBUTION OF ALPHA 1 AND ALPHA 2 GABAA RECEPTOR SUBUNITS IN DEVELOPING CHICK OPTIC TECTUM

AP11-04 Liu, H-W., Brady, S.T.
CHRONIC GLUCOCORTICOID STRESS ALTERS CORTICAL GLUTAMATE RECEPTOR COMPOSITION

AP11-05 LaNou, K.F., Kreger, J., Xu, Y., Wood, M., Berkich, D.A., Hutson, S.M.
METABOLIC INFLUENCE OF GABAPENTIN IN BRAIN

AP11-06 Marini, A.M., Banaudha, K., McCall, S., Zhu, D., Lipsky, R.
a-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID-MEDIATED NEUROPROTECTION REQUIRES TRKB RECEPTOR ACTIVATION

AP11-07 Pinzon, A., Riesgo, M.I., Noga, B.R.
VOLTAMMETRIC STUDIES OF BASAL AND ELECTRICALLY EVOKED CATHECOLAMINE RELEASE FROM LONG-TERM CULTURES OF CHROMAFFIN CELLS

AP11-08 Plaitakis, A.J., Zaganas, I.V.
GLY456 AND ARG443 ARE ESSENTIAL FOR ALLOSTERIC REGULATION OF HUMAN GLUD1 GLUTAMATE DEHYDROGENASE

AP11-09 Wieraszko, A., Hoga, M.V., El-Sherif, Y., Tesoriero, J., Raja, H.
THE INFLUENCE OF MELATONIN ON THE HIPPOCAMPAL GLUTAMERGIC SYSTEM

AP12-01 Barros, V.G., Berger, M.A., Sarchi, M.I., Martijena, I.D., Molina, V.A., Tarazi, F.I., Antonelli, M.C.
PRENATAL STRESS ENHANCES DOPAMINE AND GLUTAMATE RECEPTORS IN LIMBIC AREAS OF THE ADULT RAT BRAIN

AP12-02 Reines, A., Zarate, S., Pena, C., Rodriguez de Lores Arnaiz, G.
NMDA RECEPTOR MODULATION BY A BRAIN ENDOGENOUS FACTOR (ENDOBAIN E): EFFECTS OF ZINC, SPERMIDINE AND PH

AP12-03 Aquino-Pinero, E.E., Weisman, G., Gonzalez, F.
PHOSPHORYLATION OF MURINE P2Y2 RECEPTOR IN 1321N1 ASTROCYTOMA CELLS

AP12-04 Brand-Schieber, E., Werner, P.
DIFFERENTIAL EXPRESSION OF AMPA/KAINATE RECEPTORS IN MOUSE SPINAL CORD

AP12-05 Christmann, B., Uliasz, T.F., Hewett, S.J.
DEVELOPMENTAL EXPRESSION OF NMDA RECEPTORS IN PRIMARY CORTICAL CELL CULTURE: RELATIONSHIP TO FUNCTION AND EXCITOTOXICITY

AP12-06 Olstad, E., Qu, H., Sonnewald, U.
ALTERATIONS IN CEREBRAL METABOLISM BY THE NEUROTOXIN KAINIC ACID STUDIED BY 13C MRS

**AP12-07 Urazaev, A.K., Gafurov, B.S., Grossfeld, R.M., Lieberman, E.M.
NAAG AND NAALADASE INFLUENCE NMDA RECEPTOR ACTIVATION AND AXON-TO-GLIA SIGNALING IN CRAYFISH MEDIAL GIANT NERVE FIBERS

AP13-01 Yao, J.K., Cheng, P.
A SIMPLE AND SENSITIVE HPLC-METHOD FOR SIMULTANEOUS MONITORING OF OXIDATIVE STRESS INDICES AND MONOAMINE METABOLITES

AP13-02 Bieberich, E.
EXCHANGE OF LOCAL AND GLOBAL NEURONAL INFORMATION PROCESSING BY RECURRENT FRACTAL NEURAL NETWORKS

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Sunday afternoon scientific sessions

W02-01 Probing Apoptosis During Neuronal Development With Novel Ceramide Analogs
Bieberich, E., MacKinnon, S., Silva, J., Yu, R.K.

W02-02 The Role of GM1 and Other Gangliosides in Neuronal Function
Ledeen, R., Wu, G., Lu, Z-H.

W02-03 Regulation of Human UDP-Galactose: Ceramide b-Galactosyltransferase (CGT) Gene Expression
Yu, R.K., Tencomnao, T.

W02-04 Life Without Gangliosides
Proia, R.L.

W02-05 GM1 Ganglioside in the Treatment of Parkinson's Disease: Long-Term Clinical Experience
Schneider, J.S.

W02-06 Sphingolipids - Roads Still To Be Taken
Schengrund, C-L.

Colloquium 4 4:30 - 6:30 p.m. Ponce De Leon I, II, III (enter left)
THE EMERGING ROLE OF PEROXISOME PROLIFERATOR ACTIVATED RECEPTORS IN BRAIN
Organizer: Douglas Feinstein

C04-01 Role of PPARG and Its Natural Ligand 15D-PGJ2 in the Regulation of Microglia Activation
Minghetti, L., Bernardo, A., Ajmone-Cat, M.A., Levi, G.

C04-02 PPAR-Agonists Prevent Experimental Autoimmune Encephalomyelitis
Feinstein, D.L., Brosnan, C.F., Whitacre, C.C., Landreth, G.E., Gavrilyuk, V., Heneka, M.T.

C04-03 Agonists Specific For The Transcription Factor PPARdelta Accelerate Differentiation of Oligodendrocytes
Skoff, R.P., Bessert, D., Saluja, I., Granneman, J.

C04-04 PPARg Agonist Hinders Anit-Mog Mediated Demyelination In Vitro
Matthieu, J.-M., Honegger, P., Pershadsingh, H.A., Feinstein, D.L., Besson, D.C.

Colloquium 5 4:30 - 6:30 p.m. Ponce IV (enter center)
CONTROL OF LIFESPAN BY INSULIN/BDNF SIGNALING IN THE NERVOUS SYSTEM
Organizer: Mark Mattson

C05-01 Insulin-Like Signaling in Neurons Controls Lifespan in C. Elegans
Wolkow, C.A.

C05-02 Growth Hormone and Insulin-Like Growth Factor-1 and The Age-Related Decline in Local Cerebral Glucose Utilization
Sonntag, W.E.

C05-03 Central Leptin Gene Therapy: A Model For the Study of Caloric Restriction Induced Longevity
Kalra, P.S., Kalra, S.P.

C05-04 Dietary Restriction, BDNF Signaling and Brain Aging
Mattson, M.P., Duan, W., Lee, J., Maswood, N., Cheng, A.

Colloquium 6 4:30 - 6:30 p.m. Ponce V, VI (enter right)
NEW ROLES FOR GABA IN THE CENTRAL NERVOUS SYSTEM
Organizer: Monica Fiszman

C06-01 Estradiol Enhances Depolarizing GABA
McCarthy, M.M.

C06-02 Neocortex That Develops Without Layer 4 Results in Functional and Structural Reorganization of Gabaergic Elements
Juliano, S.L.

C06-03 GABA Promotes Neuritogenesis Via CaMKII and MAPK Kinase Pathways
Fiszman, M.L.

C06-04 Transmitter Signaling During Early Neurogenesis in the Embryonic Rat Cortex
Barker, J.L., Maric, D.

Workshop 3 4:30 - 6:30 p.m. Mediterranean Ballroom
IS DOPAMINE THE ANSWER?: OTHER SYSTEMS IN THE NEUROCHEMICAL EFFECTS OF PSYCHOSTIMULANTS
Organizer: Sari Izenwasser

W03-01 The Role of Opioids in Cocaine Abuse
Unterwald, E.

W03-04 Bidirectional Interactions Between Dopamine and Opioid
Receptors: Implications for the Regulation of Cocaine Abuse
Izenwasser, S.

W03-02 Cocaine Self-Administration in Dopamine and Norephinephrine Knockout Mice
Rocha, B.

W03-03 The Importance of Neuronal Nitric Oxide in Mediating the Effects of Psychostimulants.
Kantak, K.

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Monday, June 24, 2002

*ASN registration desk, located in South Loggia East, is open Monday, 7:15 a.m. - 1:15 p.m.

*Coffee complimentary of ASN is available in the Ponce de Leon Foyer, 7:30 a.m. - 8:30 a.m.*

*All posters beginning with BP should be posted in the Venetian room by 8:15 a.m. today and dismantled by 5:30 p.m., Monday.

*If you plan to attend the ASN Final Banquet on Wednesday evening, June 26 - please pick-up your entrance ticket at the ASN Registration desk by Monday, noon. If you do not plan to attend the banquet, please notify us.

Plenary Lecture 1 8:15 - 9:15 a.m. Ponce De Leon I, II, III, IV
Don Price

ALZHEIMER'S DISEASE: THE VALUE OF GENE TARGETING, TRANSGENIC AND EXPERIMENTAL THERAPEUTICS FOR DEVELOPING NOVEL TREATMENTS FOR THE HUMAN ILLNESS

Presentation of Marian W. Kies Memorial Award
9:15 - 9:30 a.m. Ponce De Leon I, II, III, IV
Presented by Karen Chandross, Chair, Marian W. Kies Award Committee

**********

Symposium 4 9:30 - 11:30 a.m. Ponce I, II & III (enter left) DYNAMICS OF THE NEURONAL CYTOSKELETON
Organizer: George Langford

S04-01 Actin-Based Vesicle Transport in Nerve Cell Extracts: Implications for Neurodegenerative Diseases
Langford, G.M., Brown, J.R., Simonetta, K.R., Stafford, P.

S04-02 "Stop and Go" Movement of Cytoskeletal Polymers in Axons
Brown, A.

S04-03 Alignment, Zippering and Splaying of Microtubules During Axogenesis
Baas, P.W., Yu, W., Ling, C.

Symposium 5 9:30 - 11:30 a.m. Ponce IV (enter center)
CHECKS AND BALANCES IN CHOLINERGIC GENE EXPRESSION
Organizer: Hermona Soreq and Palmer Taylor

S05-01 Wanderings In and About Active Center Gorges and Subunit Interfaces: Nicotinic Receptors and Acetylcholinesterase
Taylor, P.

S05-02 The Modulation and Function of Neuronal Nicotinic Acetylcholine Receptors
Albuquerque, E.

S05-03 Nicotine and Nicotinic Receptors
Lindstrom, J.

S05-04 Transgenic and Antisense Manipulations of Impairments in Cholinergic Balance
Soreq, H., Cohen, O., Meshorer, E., Ginzberg, D.,
Glick, D., Yirmiya, R.

Symposium 6 9:30 - 11:30 a.m. Ponce V, VI (enter right)
IMPLICATIONS OF STEM CELL PLASTICITY IN NEUROLOGICAL DISEASES
Organizer: Anne Baron-Van Evercooren

S06-01 Regulation of Neurogenesis by Epileptic Seizures and Cerebral Ischemia
Kokaia, Z.

S06-02 Possible Functions for Adult Hippocampal Neurogenesis
Kempermann, G.

S06-03 Are Endogenous Neural Stem Cells of Hematopoietic Origin?
Fallon, J.H., Kinyamu, R.

S06-04 Regulation of SVZ-Derived Gliogenesis by Inflammatory-Demyelination
Baron-Van Evercooren, A., Decker, L., Picard, N., Nait-Oumesmar, B., Lachapelle, F.

Workshop 4 9:30 - 11:30 a.m. Mediterranean Ballroom
COMPARTMENTATION OF NEURONAL METABOLISM
Organizers: Mary McKenna and Ursula Sonnewald

W04-01 Compartmentation of Energy Metabolism and Amino Acid Synthesis in Synaptosomes
McKenna, M.C., Hopkins, I.B., O'Brien, J.A., Carey, A.

W04-02 Neuronal/Astrocyte Compartmentation and Neurodegeneration
Clark, J.

W04-03 Metabolic Compartmentation Leads to Selective Vulnerability of Neurons
Heales, S.

W04-04 Brain Amino Acid Metabolism During Ketosis
Yudkoff, M.

W04-05 New Aspects of Amino Acid Neurotransmitter Synthesis in Cultured Neurons
Sonnewald, U., Waagepetersen, H., Qu, H.,
Schousboe, A.

W04-06 Compartmentalized Neurotransmitter and Amino Acid Synthesis In Vivo Studied by High Field MRS
Gruetter, R., Henry, P.-G., Lei, H., Choi, I.-Y.

W04-07 Complexity of GABA biosynthesis: What Did We Learn From 13C-NMR
Schousboe, A., Sonnewald, U., Waagepetersen, H.S.

Lunch (on your own) 11:30 a.m. - 1:00 p.m.

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Monday afternoon, June 24, 2002

Poster Presentations/Exhibits 1:00 - 2:30 p.m. Venetian Ballroom
** note: BP07-09 will be displayed Sunday.

BP01-01 Navarro, D., Zwingmann, C., Hazell, A.S., Liebfritz, D., Butterworth, R.F.
NMR INVESTIGATION OF METABOLIC ALTERATIONS IN THE BRAIN OF THIAMINE-DEFICIENT RATS

BP01-02 Pan, J.W., de Graaf, R.A., Rothman, D.L., Hetherington, H.P.
13C-[2, 4]-B-HYDROXYBUTYRATE METABOLISM IN HUMAN BRAIN

BP01-03 Zeevalk, G.D., Ehrhart, J.
FUNCTIONAL GLUTAREDOXIN ACTIVITY IN RAT BRAIN & LIVER MITOCHONDRIA

BP02-01 Thomas, S., Gollapudi, L., DeVries, G.H.
RAS ACTIVATION REGULATES ANGIOGENIC AND ANTI-ANGIOGENIC FACTOR EXPRESSION IN NF1-DERIVED SCHWANN CELLS

BP02-02 Muja, N., Lovas, G., Romm, E., Machleder, D., Ranjan, M., Hudson, L.D.
TRANSGENIC MICE EXHIBITING OLIGODENDROCYTE-SPECIFIC EXPRESSION OF A MUTANT PROTEIN TYROSINE PHOSPHATASE EPSILON

BP02-03 Knapp, P.E., Adams, M.H., Holder, J.M., Hudig, D.
PERFORIN AND GRANZYME MEDIATED TOXICITY ON CULTURED OLIGODENDROCYTES

BP02-04 Knapp, P.E., Rizzo, J.P., Alimova, Y., Singh, I., Goody, R.J., Hauser, K.F.
GLUTAMATERGIC EFFECTS OF DYNORPHIN PEPTIDES ON CULTURED OLIGODENDROCYTES

BP02-05 Shafit-Zagardo, B., Shankar, S.L., O'Guinn, K., McMorris, F.A., Stitt, T., Varnum, B., Basch, R.S.
GAS6 ENHANCES HUMAN OLIGODENDROCYTE VIABILITY AND MATURATION

BP02-06 Nielsen, J.A., Hudson, L.D., Armstrong, R.C.
MYELIN TRANSCRIPTION FACTOR 1 FUNCTION IN OLIGODENDROCYTE DEVELOPMENT

BP02-07 Paez, P., Pasquini, J., Soto, E.
APOTRANSFERRIN ENHANCES DIFFERENTIATION OF TWO OLIGODENDROGLIAL CELL LINES

BP02-08 Bhat, N.R., Fan, F., Pawate, S.
AN ESSENTIAL ROLE FOR P38 MAP KINASE SIGNALING IN OLIGODENDROCYTE DIFFERENTIATION

BP02-09 Saini, H.S., Chu, A.K., Boxer, L.M., Sato-Bigbee, C.
SIGNALING PATHWAYS LINKING PROLIFERATION AND SURVIVAL IN OLIGODENDROCYTE PROGENITORS

BP02-10 Roth, A.D., Leisewitz, A.V., Inestrosa, N.C., Bronfman, M.
PPAR GAMMA ACTIVATORS INDUCE DIFFERENTIATION OF B12 OLIGODENDROCYTE-LIKE CELLS AND RAT SPINAL CORD OLIGODENDROCYTES

BP03-01 Toews, A., Jurevics, H., Hostettler, J., Sammond, D., Morell, P.
MYELIN AND MYELINATION IN PLP-NULL MICE

BP03-02 Morell, P., Jurevics, H., Largent, C., Hostettler, J., Sammond, D., Matsushima, G., Toews, A.
METABOLISM AND GENE EXPRESSION DURING CUPRIZONE-INDUCED DEMYELINATION/REMYELINATION

BP03-03 Wei, Q., Miskimins, W.K., Miskimins, R.
MOLECULAR BASIS OF P27 ENHANCEMENT OF MYELIN BASIC PROTEIN GENE PROMOTER ACTIVITY

BP03-04 Levison, S.W., Albrecht, P.J., Murtie, J.C., Ness, J.K., Redwine, J.M., Armstrong, R.C.
CNTF IS UPREGULATED IN ASTROCYTES DURING SPINAL CORD REMYELINATION AND STIMULATES FGF-2 PRODUCTION

BP03-05 Connor, J.R., Thompson, K., Ortiz, E., Pasquini, J.M.
MANIPULATION OF BRAIN IRON STATUS IN TWO MUTANT MOUSE MODELS: EFFECTS ON MYELIN

BP03-06 Brand-Schieber, E., Werner, P.
CA2+ BLOCKERS AMELIORATE DISEASE IN MOUSE MODEL OF MULTIPLE SCLEROSIS (MS)

BP03-07 Konat, G.W., Tirumalai, P.
HYPOCHLORITE-INDUCED WHITE MATTER DAMAGE

BP03-08 Paintlia, A.S., Singh, A.K., Singh, I.
THE ROLE OF INFLAMMATORY MEDIATORS IN THE PATHOPHYSIOLOGY OF X-ALD DISEASE

BP03-09 Bizzozero, O.A., Malkoski, S.P., Mobarak, C.D., Evans, J.E., DeJesus, G.
STRUCTURE AND REGIONAL DISTRIBUTION OF LOW MOLECULAR WEIGHT MYELIN PROTEOLIPIDS

BP03-10 Boullerne, A.I., Schmidt, S., Brochet, B., Jensen, M.A., Petry, K.G., Arnason, B.G.W.
ANTI-NITROSOCYSTEINE ANTIBODIES IN MULTIPLE SCLEROSIS: EMERGENCE OF A NEW MARKER OF CLINICAL ACTIVITY

BP03-11 Shinar, Y., Livneh, A., Vila, Y., Pinhasov, A., Seitoun, I., Achiron, A.,
THE MEDITERRANEAN FEVER GENE MODIFIES THE PROGRESSION OF DISABILITY IN NON-ASHKENAZI JEWISH MULTIPLE SCLEROSIS PATIENTS

BP04-01 Jana, M., Dasgupta, S., Liu, X., Pahan, K.
INTERLEUKIN-12 P40 INDUCES THE EXPRESSION OF TNF-ALPHA IN MICROGLIA AND MACROPHAGES

BP04-02 Jana, M., Dasgupta, S., Liu, X., Pahan, K.
STIMULATION OF INDUCIBLE NITRIC OXIDE SYNTHASE IN MICROGLIAL CELLS BY CD40 LIGATION

BP04-03 Connor, J.R., Cheepsunthorn, P., Reid, J., Radov, L.A.
IRON MEDIATES GENE EXPRESSION IN ACTIVATED MICROGLIA

BP04-04 Krady, J.K., Basu, A., Enterline, J.R., Levison, S.W.
ANTI-INFLAMMATORY ACTIONS OF TRANSFORMING GROWTH FACTOR-b1 ON RAT MICROGLIA

BP04-05 Dello Russo, C., Gavrilyuk, V., Feinstein, D.L.
INTER-RELATIONSHIP OF CYTOKINE PRODUCTION AND NOS2 EXPRESSION IN MICROGLIA

BP04-06 Bhat, N.R., Fan, F.
ADENOVIRUS INFECTION INDUCES MICROGLIAL ACTIVATION: INVOLVEMENT OF MITOGEN-ACTIVATED PROTEIN KINASE PATHWAYS

BP04-07 Zheng, Q., Binek, J., Sun, G.Y.
INHIBITION OF INTERFERON-GAMMA-INDUCED NITRIC OXIDE PRODUCTION IN BV-2 MICROGLIAL CELLS BY POLYPHENOLIC COMPOUNDS

BP05-01 Dasgupta, S., Zhou, Y., Jana, M., Pahan, K.
INHIBITION OF ADOPTIVE TRANSFER OF EAE BY NEMO-BINDING DOMAIN (NBD) PEPTIDES

BP05-02 Dasgupta, S., Jana, M., Liu, X., Pahan, K.
INDUCTION OF NITRIC OXIDE SYNTHASE IN MICROGLIAL CELLS BY MBP-PRIMED T CELLS

BP05-03 Anderson, J.A., Jana, M., Dasgupta, S., Liu, X., Pahan, K.
INVOLVEMENT OF P38MAP KINASE IN THE INDUCTION OF NITRIC OXIDE SYNTHASE IN HUMAN ASTROCYTES

BP05-04 Pahan, K., Jana, M., Dasgupta, S., Liu, X.
INDUCTION OF NITRIC OXIDE SYNTHASE IN CYTOKINE-STIMULATED HUMAN ASTROCYTES BY INTERLEUKIN-12 P40 MONOMER

BP05-05 Auch, C.J., Dasgupta, S., Jana, M., Liu, X., Pahan, K.
DOUBLE-STRANDED RNA INDUCES NITRIC OXIDE SYNTHASE IN HUMAN ASTROCYTES

BP05-06 Rocchini, A., Schaecher, K., Goust, J.M., Banik, N.L.
EFFECTS OF CALPAIN INHIBITION OF IKBA DEGRADATION FOLLOWING PBMC ACTIVATION: IDENTIFICATION OF CALPAIN CLEAVAGE SITES

BP05-07 Zhu, W., Cadet, P., Stefano, G.B.
LPS AND IL-1a INCREASE ENDOGENOUS MORPHINE PRODUCTION IN MOLLUSK (MYTILUS EDULIS) PEDAL GANGLIA

BP05-08 Rattan, R., Giri, S., Singh, I.
LOVASTATIN INDUCED CYTOKINE-MEDIATED INDUCIBLE NITRIC OXIDE SYNTHASE (INOS) EXPRESSION IN BRAIN TRANSFORMED CELL LINES

BP05-09 Alexander, J.J., Bao, L., Anderson, R., Quigg, R.J.
COMPLEMENT INHIBITION AMELIORATES LUPUS CEREBRITIS IN NZB/W AND MRL/LPR MICE

BP06-01 Qiu, J., Grafe, M.R., Martin, S.S., Kent, T.A., Rassin, D.K., Perez-Polo, J.R.
"DECOY" OLIGONUCLEOTIDES' EFFECTS ON NF-KB REGULATION OF BCL-X GENE EXPRESSION IN RAT HIPPOCAMPUS

BP06-02 Benjamins, J.A., Nedelkoska, L.
CYCLIC GMP IS MORE EFFECTIVE THAN CYCLIC AMP OR GDNF IN PROTECTING MATURE OLIGODENDROCYTES FROM CELL DEATH

BP06-03 Ray, S.K., Nowak, M.W., Li, L., Wilford, G.G., Banik, N.L.
PREVENTION OF APOPTOSIS AND PRESERVATION OF FUNCTION BY PROTEASE INHIBITORS IN CORTICAL NEURONS EXPOSED TO GLUTAMATE

BP06-04 Lee, J., Seroogy, K.B., Mattson, M.P.
DIETARY RESTRICTION ENHANCES NEUROGENESIS AND UP-REGULATES NEUROTROPHIN EXPRESSION IN THE HIPPOCAMPUS OF ADULT MICE

BP06-05 Liour, S.S., Suetake, K., Wen, J., Warsi, S., Kraemer, S., Yu, R.K.
CHARACTERIZATION OF MOUSE MARROW STROMAL CELLS

BP06-06 Diza-Pimentel, J.A., Vivas, P., Weisman, G., Gonzalez, F.A.
INVOLVEMENT OF P38 MAP KINASE IN P2X7 RECEPTOR-DEPENDENT CELL DEATH

BP06-07 Cohen, R.I.
PURIFICATION AND PLASTICITY OF HUMAN CORD BLOOD MESENCHYMAL STEM CELLS

BP06-08 Espinosa-Jeffrey, A., Zhao, P.M., Becker-Catania, S.G., Cole, R.,
de Vellis, J.
IN VITRO SPECIFICATION OF CNS STEM CELLS INTO EITHER OLIGODENDROCYTES OR NEURONS: THEIR FATE IN VIVO

BP06-09 Banerjee, P., Adayev, T., Sondhi, R., Sobocki, T.
ROLE OF PKCALPHA IN LINKING MAP KINASE TO CASPASE-3 IN 5-HT1A RECEPTOR MEDIATED SIGNALING

BP07-01 Jayman, F., Duchatellier, R., Anantharam, V., Kanthasamy, A., Banerjee, P.
THE ROLE OF ALPHA-SYNUCLEIN IN CELL DIVISION, DIFFERENTIATION AND SURVIVAL

BP07-02 Chauhan, A., Chauhan, V.
A NEW METHOD FOR MEASURING FIBRILLAR AMYLOID BETA-PROTEIN USING DIPHENYLHEXATRIENE, A FLUORESCENT PROBE

BP07-03 Chera, B.S., Schaecher, K., Ray, S., Rocchini, A., Inam, S., Ali, S.,
Banik, N.
SPINAL CORD NEURON DEATH IN METHYL-4-PHENYL-1,2,3,6 TETRAHYDROPYRIDINE INDUCED PARKINSONISM

BP07-04 Mattson, M.P., Cutler, R.G., Pedersen, W.A.
PERTURBED SPHINGOMYELIN METABOLISM AND ACCUMULATION OF CERAMIDES AND CHOLESTEROL ESTERS IN ALZHEIMER'S DISEASE AND ALS

BP07-05 Poduslo, J.F., Wengenack, T.M., Curran, G.L., Wisniewski, T., Sigurdsson, E.M., Macura, S.I., Borowski, B.J., Jack, C.R.
MOLECULAR TARGETING OF ALZHEIMER'S AMYLOID PLAQUES FOR CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING

BP07-06 Pelsman, A., Busciglio, J.
A ROLE FOR THE TRANSCRIPTION FACTOR ETS-2 IN DOWN'S SYNDROME NEUROPATHOLOGY

BP07-07 Boldyrev, A.A., Sorokina, E., Kasey, V., Bastrikiva, N., Fedorova, T., Stvolinsky, S.
MPTP-TREATED SENESCENCE ACCELERATED MICE AS A NOVEL EXPERIMENTAL MODEL FOR PARKINSON'S DISEASE

BP07-08 (not shown as a poster presentation; see Cooper's session Monday, June
24 at 4:30 p.m.)

**BP07-09 Thomas, A.G., Corse, A.M., Coccia, C.F., Wozniak, K.M., Hartman, T., Jada, P. Chandran, M., Rothstein, J.F., DalCanto, M., Slusher, B.S.
NAALADASE (GCP II) INHIBITORS PROTECT IN MODELS OF AMYOTROPHIC LATERAL SCLEROSIS (ALS)

BP07-10 Feinstein, D.L., Galea, E., Gavrilyuk, V., O'Banion, M.K., Heneka, M.T.
NORADRENDERGIC DEPLETION POTENTIATES B-AMYLOID INDUCED CORTICAL INFLAMMATION: IMPLICATIONS FOR ALZHEIMER'S DISEASE

BP07-11 Lukiw, W.J., Rogaev, E.I., Schurr, J., Carver, L.A., LeBlanc, H.J., Howse, K., Ball, M.J., Bazan, N.G.
ANALYSIS OF 12360 POLY A+ RNA MESSAGE LEVELS IN ALZHEIMER DISEASE (AD) HIPPOCAMPAL CA1

BP07-12 Lopez Salon, M, Castano, E., Soto, E., Pasquini, J.
DISPLACEMENT TOWARD NFT OF A KEY ENZYME OF THE UBIQUITIN PROTEOLYTIC PATHWAY IN ALZHEIMER'S BRAIN

BP07-13 McIlvain, H.B., She, Y., Howland, D.S., Dunlop, J.
SYNAPTOSOMAL GLUTAMATE TRANSPORT STUDIES IN A TRANSGENIC RAT MODEL OF AMYOTROPHIC LATERAL SCLEROSIS

BP07-14 Yusof, M., Sun, A.
COPPER AND AMYLOID BETA: INTERACTIONS IN ALZHEIMER'S DISEASE

BP07-15 Kim, S.H., Heo, C.J., Im, P.S., Suh, Y.-H.
CHARACTERIZATION OF A-SYNUCLEIN IN IMMUNE SYSTEM

BP07-16 Bliznakov, E.G., Bhagavan, H.N.
OXIDATIVE STRESS, BIOENERGETICS AND NEURODEGENERATIVE DISEASES

BP08-01 Cyr., J.L.
STICKING OUT ITS NECK: MYOSIN-1C BINDING TO HAIR-CELL RECEPTORS REQUIRES ITS IQ DOMAINS AND IS REGULATED BY CALMODULIN

BP08-02 Wray, R., Szebenyi, G., Brady, S.T.
CST1 ANTIBODY SPECIFICALLY RECOGNIZES COLD STABLE TUBULIN

BP08-03 Liu, H-W., Brady, S.T.
NEURONAL COLD-STABLE TUBULIN INDUCED BY CHRONIC GLUCOCORTICOID STRESS

BP08-04 Galiano, M.R., Soto, E.F., Pasquini, J.M., Hallak, M.E.
EXPRESSION OF THE MICROTUBULE-ASSOCIATED PROTEIN STOP IN OLIGODENDROCYTES

BP08-05 Ortiz, E., Pasquini L., Galiano, M., Hallak, M., Soto, E., Pasquini, J.
EFFECTS OF APOTRANSFERRIN UPON DIFFERENT COMPONENTS OF THE CYTOSKELETON IN PRIMARY OLIGODENDROGLIAL CELL CULTURES

BP08-06 Lee, J., Gravel, M., Braun, P.E.
IS THE INTERACTION OF CNP WITH TUBULIN AND MICROTUBULES REQUIRED FOR PROCESS EXTENSION IN OLIGODENDROCYTES?

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Monday afternoon scientific sessions

Colloquium 7 2:30 - 4:30 p.m. Ponce De Leon I, II, III (enter left)

DIFFERENTIAL FUNCTION OF MICROGLIA AND MACROPHAGES IN CNS INFLAMMATION
Organizer: Monica J. Carson

C07-01 Microglial Regulation Through Interactions With Neuronal Ligands Triggering Myeloid Inhibitor and Activating Receptors
Hoek, R.H., Sedgwick, J.D., Cherwinski, H., Phillips, J., Ruuls, S., Murphy, C., Joyce-Shaikh, B.

C07-02 Microglia and Perivascular Macrophages in CNS HIV/SIV Infection.
Williams, K.

C07-03 Revealing Microglia and Macrophage Function After Traumatic Spinal Cord Injury
Popovich, P.G., Hickey, W.F., McGaughy, V.M., Guan, Z.

C07-04 Microglia As Liasons Between the Immune and Central Nervous Systems
Carson, M.J., Schmid, C.D., Hilbush, B.S., Sutcliffe, J.G.

Colloquium 8 2:30 - 4:30 p.m. Ponce De Leon IV (enter center)
Ab DEGREDATION AND CLEARANCE IN ALZHEIMER'S DISEASE
Organizers: Mark Kindy and Louis Hersh

C08-01 Neprilysin Regulation of Amyloid Deposition in Alzheimer's Disease
Hersh, L.B., Yu, J., Zhu, H., Gao, J.-T., Mucke, L.,
Kindy, M.S.

C08-02 The Role of Thiol Oligopetidase 1 (THOP1) in Amyloid Beta Degradation
Abraham, C.

C08-03 Degradation of the Alzheimer's Amyloid Beta Peptide by Endothelin Converting Enzyme
Eckman, C.B., Edkman, E.A., Watson, M.L.

C08-04 Does the Plasmin System Contribute to Amyloid beta Clearance?
Estus, S.

Colloquium 9 2:30 - 4:30 p.m. Ponce De Leon V, VI (enter right)
STRUCTURAL AND MOLECULAR DISSECTION OF THE NODE OF RANIER
Organizers: Kazuhiro Ikenaka and David Colman

C09-01 Sodium Channel b Subunits: Multifunctional Molecules at The Node of Ranvier
Isom, L.L.

C09-02 The Myelin Membrane Influences the Organization of Molecules on The Axonal Surface
Pedraza, L., Huang, J.K., Svenningsen, A.F.,
Colman, D.R.

C09-03 The Molecular Composition Around the Node of Ranier
Baba, H.

C09-04 How To Dissect the Node of Ranvier
Rasband, M.N., Park, E.W., Zhen, D.K., Trimmer, J.S

.Workshop 5 2:30 - 4:30 p.m. Mediterranean Ballroom
NAAG AND NAALADASE: FUNCTIONAL PROPERTIES IN THE CENTRAL AND PERIPHERAL NERVOUS SYSTEMS
Organizers: Edward Lieberman and Barbara Slusher

W05-01 NAALADase (GCPII) Knockout Mice are Less Susceptible to Neuropathy and Stroke
Bacich, D., O'Keefe, D.S., Heston, W.D.W., Callizot, N., Poindron, P., Baillet, C., Tiffany, C., Lu, X.-C., Wozniak, K.M., Slusher, B.S.

W05-02 Probing The Functions of NAAG Via NAAG Peptides and MGLUR3
Wroblewska, B., Ramadan, E., Bacich, D.J., O'Keefe, D.S., Heston, W.D.W., Bukharil, N., Wegorzewska, I., Bzdegal, T., Wroblewski, J.T., Kozikowski, A., Yamamoto, T., Neale, J.H.

W05-03 The Role of NAAG and NAALADase In Axon-to-Glia Signaling
Grossfeld, R.M., Urazaev, A.K., Lieberman, E.M.

W05-04 NAALADase (GCP II) Inhibition As a Novel Therapeutic Target For Neuropathic Pain, Diabetic Neuropathy, and ALS
Slusher, B.S., Rojas, C., Sima, A., Majer, P., Tsukamoto, T., Jackson, P.J., Dal, Canto, M., Lu, X.M., Vomov, J.J., Burak, E., Rhodes, C., Limsakun, T., Potter, B.,
Wozniak, K.

W05-05 Lieberman, E. M.
(W05-05 will be shown as a poster presentation, Sunday, June 23 and located next to poster AP12-07.)

Workshop 6 4:30 - 6:30 p.m. Ponce de Leon I, II & III (enter left)
MICROGLIAL ACTIVATORS AND INACTIVATORS
Organizer: Steve Levison

W06-01 Mechanisms of Induction and Repression of CD40 in Microglia/Macrophages
Benveniste, E., Nguyen, V.T., Wesemann, D., O'Keefe, G.M.

W06-02 Neuropeptide Regulation of Microglial Function
Jonakait, G.M., Kim,W.-K., Delgado, M., Su, Y., Ganea, D.

W06-03 Hierarchical Interactions Among Cytokines Establish the Functional State of Microglia
Levison, S.W.

W06-04 CD36 Null Mice Reveal a Key Role For CS36 in Beta-Amyloid Induced Microglial Activation
El Khoury, J.B., Moore, K., Freeman, M., Luster, A.D.

Workshop 7 4:30 - 6:30 p.m. Ponce de Leon IV (enter center)
GLUTAMATE AND GLUTAMINE TRANSPORTERS: POTENTIAL TARGETS FOR MODULATING PRESYNAPTIC GLUTAMERGIC FUNCTION
Organizer: Jeffrey Erickson

W07-01 Amino Acid Exchange Between Astrocytes and Neurons
Schousboe, A., Sonnewald, U., Waagepetersen, H.S.

W07-02 Facilitated Flux of Glutamine Through Glutamate Transporters
Kavanaugh, M.

W07-03 Mechanisms of The System A Neuronal Glutamine Transporter SAT1
Mackenzie, B., Hediger, M.A., Varoqui, H.

W07-04 Redefining Chemical Anatomy of Glutamatergic Neurotransmission
Schafer, M.K., Weihe, E.

Workshop 8 4:30 - 6:30 p.m. Ponce de Leon V, VI (enter right)
BIOCHEMICAL/SURROGATE MARKERS OF ACUTE CNS INJURY
Organizers: Ronald L. Hayes and Kevin K.W. Wang

W08-01 Cerebrospinal Fluid Markers of Neurodegenerative Disorders with Emphasis on Alzheimer's Disease
Sjogren, M., Blennow, K.

W08-02 MR Markers For The Injured Brain and Spinal Cord
Hsu, C.Y., Lee, J-M., Vo, K., Hsu, C.Y., Song, V., Lin, W.

W08-03 S100B and NSE As A Serum Marker for Focal and Global Brain Ischemia
Jonsson, H.

W08-04 Accumulation of Spectrin and Calpain-Cleaved Spectrin Breakdown Products in CSF After Traumatic Brain Injury in Rats
Pike, B.R., Flint, J., Dutta, S., Wang, D.S., Wang, K.K.W., Hayes, R.L.

Workshop 9 4:30 - 6:30 p.m. Mediterranean Ballroom
THE ROLE OF TRANSGLUTAMINASES IN NORMAL BRAIN FUNCTION AND NEURODEGENERATION - AN UPDATE
Organizer: Arthur Cooper

W09-01 Transglutaminases in Huntington Brain: Possible Relation to Selective Vulnerability
Kim, S.-Y., Browne, S.E., Cooper, A.J.L., Blass, J.P.

W09-02 Transglutaminase Cross-Linking of Proteins in Tauopathies and Huntington's Disease
Muma, N.A., Zainelli, G.M., Halverson, R.A., Zemaitaitis

W09-03 Does Tissue Transglutaminase Play a Role in Huntington's Disease?
Johnson, G.V.W., Tucholski, J., Lesort, M., Bailey, C.D.C., Chun, W.
(this abstract is shown as BP07-08 in Journal of Neurochemistry)

W09-04 Induction of Neuroprotective Molecules for Hungtinton's Disease With TGASE Inhibition
Steinman, L., Steinman, L., Karpuj, M.

W09-05 Tissue Transglutaminase: Transcriptional Regulation and Roles in Age-Dependent Neurodegenerations
Festoff, B., Suo, Z., Citron, B.

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Tuesday, June 25, 2002

*ASN registration desk, located in South Loggia East, is open Tuesday, 7:15 a.m. - 1:15 p.m.

*Coffee complimentary of ASN is available in the Ponce de Leon Foyer, 7:30 - 8:30 a.m.*

*Have you purchased your ticket for "WO/MEN and Tenure: Is It Time for a Change?" The session is at noon, today in Mediterranean Ballroom.

Plenary Lecture 2 8:15 - 9:15 a.m. Ponce de Leon I, II, III & IV
SYNUCLEIN INCLUSIONS: THE SECOND AMYLOID IN TAUPATHIES
Virginia Lee

Presentation of Jordi Folch-Pi Memorial Award
9:15 - 9:30 a.m. Ponce de Leon I, II, III & IV
Presented by Regina Armstrong, Chair, Jordi Folch-Pi Award Committee

Symposium 7 9:30 - 11:30 a.m. Ponce de Leon I, II, III (enter left)
THE EMERGENCE OF NEUROBIOTECHNOLOGY
Organizers: Nicolas Bazan and Gino Toffano

S07-01 Molecular Targeting in Neuroprotection
Bazan, N.

S07-02 Semliki Forest Virus Vectors: Applications in
Neurobiotechnology and Gene Therapy.
Lundstrom, K.

S07-03 Molecular Regulation of Neuron-Astrocyte Homeostasis in the Adult CNS
Weinstein, D.

S07-04 Whole-Genome Expression in Brain and Body
Walker, J.

S07-05 Strategies for Target Validation in Drug Discovery
Hunter, J.

Symposium 8 9:30 - 11:30 a.m. Ponce de Leon IV REGULATION OF OLIGODENDROCYTE DEVELOPMENT
Organizer: Rashmi Bansal

S08-01 Guidance of Oligodendrocyte Precursor Migration in The Developing Spinal Cord
Miller, R.H., Wang, R-Z., Tsai, H-H.

S08-02 Regulation of Development of Oligodendrocytes
Ikenaka, K.

S08-03 Fibroblast Growth Factor Receptor-3 Null Mice Exhibit a Delay in The Development of Oligodendrocytes and Myelination
Bansal, R., Luke, Y.S.

S08-04 The Oligodendrocyte Lineage Genes OLIG1 and OLIG2 in CNS Development
Stiles, C.D., Lu, Q.R., Sun, T., Rowitch, D.H.

Symposium 9 9:30 - 11:30 a.m. Ponce de Leon V, VI (enter right) mRNA AND PROTEIN TRAFFICKING IN NEURONS
Organizer: Kelsey Martin, 2001 recipient of Jordi Folch-Pi Memorial Award

S09-01 mRNA Trafficking and Local Translation During Synapse Specific Plasticity
Martin, K.

S09-02 Regulation of Growth after Nerve Injury: Role for a Retrogradely Transported Signal that Activates the Serum Response Element Transcription Complex
Ambron, R.

S09-03 mRNA and Protein Synthesis in the Axon and Presynaptic Nerve Terminal
Kaplan, B.

S09-04 RNA Translocation and Local Translation in Neurons
Kosik, K.

Workshop 10 9:30 - 11:30 a.m. Mediterranean Ballroom
GENE EXPRESSION PROFILING OF ALZHEIMER'S DISEASE DEMENTIA
Organizer: Giulio Maria Pasinetti

W10-01 The Molecular Biology of Mild Cognitive Impairment
Pasinetti, G.M.

W10-02 Regional Gene Expression Profile Analysis in Alzheimer's Disease
Lee, J.

W10-03 Confirming Brain Microarray Results with RT-PCR and Functional Studies
Haroutunian, V.

W10-04 The Neuromodulatory and Neurophysiological Effects of the Herbal Medicine Ginko Biloba
Watanabe, C.

Lunch on Your Own 11:30 a.m. - 1:30 p.m.

Noon - 1:00 PM "WO/MEN and Tenure: Is It Time for Some Changes?" a social and panel discussion during lunch in the Mediterranean Ballroom sponsored by Women in Neurochemistry. All ASN members are invited. $5 advance ticket must be purchased by Monday, 1p.m. from the ASN registration desk. Ticket includes admission and beverage. Grab a sandwich in advance at the Breakers News & Gourmet, bring to the session and then join WIN for an interactive, informative discussion.

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Tuesday afternoon, June 25

Oral Presentations 1:30 - 2:30 p.m.

NEURODEGENERATIVE DISEASES Ponce de Leon I, II, III (enter left)
Co-Chairs: Jean-Marie Mathieu and Scott Brady

OP01-01 BCL-W Plays a Key Neuroprotective Role in Alzheimer's Disease
Zhu, X., Wang, Y., Ogawa, O., Lee, H.G., Raina, A.K., Fujioka, H., Shimonana, S., Atwood, C.S., Petersen, R.B., Perry, G., Smith, M.A.

OP01-02 DNA Polymorphism in The Human Presenilin-2 Promoter: Altered Gene Activity and Potential Contribution to The Risk for AD
Lukiw, W.J., Raizanskaya, N., Grigorenko, A., Korovaitseva, G., Dvoryanchikov, G., Molyaka, Y., Nicolaou, M., Farrer, L., Bazan, N.G., Rogaev, E.I.

OP01-03 A Novel Oxidative Stress Dependent Apoptotic Pathway in Pesticide-Induced Dopaminergic Degeneration in PD Models
Kanthasamy, A., Kitazawa, M., Kaul, S., Anantharam, S.V., Kanthasamy, A.G.

OP01-04 Proteins with Pathogenic Polyglutamine Expansion Inhibit Fast Axonal Transport
Szebenyi, G., Morfini, G., Young, M., Sheridan, S., McPhaul, M.J., Brady, S.T.

MYELIN AND DISEASES OF MYELIN (Oral Presentaions)
Chair: David Colman Ponce de Leon IV (enter center)

OP02-01 NPP2, A Matricellular Protein Expressed During Myelination, Actively Modulates Oligodendrocyte Adhesion
Fox, M.A., Bowlin, G., Fuss, B.

OP02-02 Promoter Analysis of The CMT1A-Disease Gene PMP22 In Vivo
Maier, M., Berger, P., Nave, K.A., Suter, U.

OP02-03 Aggregation of Peripheral Myelin Protein 22 In Trembler J Neuropathy Nerves
Notterpek, L., Fortun, J., Ferguson, T.A.

OP02-04 Apoptosis of Neurons in Rats with Experimental Allergic Encephalomyelitis
Guyton, K., Wingrave, M., Rocchini, A., Scheacher, K., Ray, S., Banik, N.

NEUROTOXICITY AND NEUROPROTECTION (Oral Presentations)
Chair: Mary McKenna Ponce de Leon V, VI (enter right)

OP03-01 Salsolinol, A Neurotoxin Causing Parkinsonism Decreases the Expression of Metallothionein and BCL-2 in Human Dopaminergi
Ebadi, M., Shavali, S.

OP03-02 NSAIDs Protect Dopaminergic Neurons Against 6-OHDA and MPP+ Toxicity
Werner, P., Carrasco, E.

OP03-03 Elevation of Cyclin D1 Following Trimethyltin Induced Hippocampal Neurodegeneration
Wine, R.N., McPherson, C.A., Harry, G.J.

OP03-04 Neuroprotection With Caspase-9 Inhibition Against In Vitro and In Vivo Trauma
Wallis, R.A., Panizzon, K.L., Shin, D.

Colloquium 10 2:30 - 4:30 p.m. Ponce de Leon I, II, III (enter left)
TRANSPORT OF NEUROTROPHINS AND THEIR RECEPTORS
Organizer: Moses Chao

C10-01 Interacting Proteins of Neurotrophin Receptors
Chao, M.V., Yano, H.

C10-02 NGF Signaling From Endosomes
Mobley, W., Howe, C., DelCroix, J-D., Beattie, E.

C10-03 Regulation of Axonal Transport by Receptor Signaling
Brady, S.T.

C10-04 Retrograde NGF Signaling and Survival in Compartmentalized Sympathetic Neurons
Ginty, D.D., Ye, H., Kuruvilla, R.

Colloquium 11 2:30 - 4:30 p.m. Ponce de Leon IV (enter center)
IRON AND COPPER IN NEURODEGENERATIVE DISEASES
Organizer: James R. Connor

C11-01 What We Have Learned About the Role of Iron in Neurobiology from Neurological Diseases?
Connor, J.R.

C11-02 Transcriptional Mechanisms of Neuroprotection by Iron Chelators
Ratan, R.R., Semenza, G., Ryu, H., Zaman, K., Aminova, L., Lee, J., Kung, A., Mwidau, A.

C11-03 The Role of Multi-Copper Oxidases in Neurodegeneration
Harris, Z.L.

C11-04 Neuroprotective Properties of Copper Binding Fragments of Amyloid Precursor Protein and Prion
Inestrosa, N.C., Chacon, M., Barria, M.I., Varela-Nallar, L., Opazo, C.

Colloquium 12 2:30 - 4:30 p.m. Ponce de Leon V, VI (enter right)
FROM CNS INFLAMMATION TO REPAIR: GENOMICS-BASED GENE DISCOVERY
Organizers: Karen Chandross and Jean Merrill

C12-01 The Use of Gene Profiling to Identify Instructive Signals in the Brain.
Chandross, K., Merrill, J.,

C12-02 From Hematopoiesis to Neuropoiesis: Evidence of Overlapping Genetic Programs
Terskikh, A.V., Esterday, M.C., Li, L., Hood, L., Kornblum, H.I., Geschwind, D.H., Weissman, I.L.

C12-03 Large Scale Transcriptional and Proteomic Analysis of Lesion Material in Multiple Sclerosis.
Steinman, L.

C12-04 Use of Pharmacogenomics in Clinical Trials for Multiple Sclerosis
Martin, R.

Workshop 11 2:30 - 4:30 p.m. Mediterranean Ballroom
HORMONAL CONTROL OF CEREBRAL AMYLOIDOGENESIS IN ALZHEIMER'S DISEASE
Organizer: Sam Gandy

W11-01 Inter and Intracellular Signals Regulating Alzheimer's Abeta Generation
Buxbaum, J.D.

W11-02 Estrogen Lowers Alzheimer b-Amyloid Generation by Stimulating Trans-Golgi Network Vesicle Biogenesis
Xu, H., Greenfield, J.P., Cai, D., Leung, L.W., Kassik, K., Rodriguez-Boulan, E., Greengard, P.

W11-03 Increased Susceptibility of Female APP-Transgenic Mice to Cerebral Abeta Proteopathy
Walker, L.C., Bian, F., Lipinski, W.J., Durham, R.A., Watson, M.D., Perez, S., Ziegler, T., Callahan, M.J.

W11-04 Estrogen Reduces Abeta Peptide Levels and Amyloid Deposition in APP Transgenic Mice
Kindy, M.S., Yu, J., Zhu, H., Kovetcheva-Ivanova, S., Maeda, N.

ASN Business Meeting 4:30 - 6:30 p.m. Ponce De Leon IV (enter center)
(all ASN members are encouraged to attend)

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Wednesday, June 26, 2002

*ASN registration desk, located in South Loggia East, is open Wednesday, 7:15 a.m. - 1:15 p.m.

*Coffee complimentary of ASN is available in the Ponce de Leon Foyer, 7:30 - 8:30 a.m.*

*All posters beginning with CP should be posted in the Venetian room by 8:15 a.m. today and dismantled by 2:45 p.m., today.

Plenary Lecture 3 8:30 - 9:30 a.m. Ponce De Leon I, II, III, IV

UNFOLDING THE PATHOGENESIS OF POLYGLUTAMINE-INDUCED NEURODEGENERATION
Huda Zoghbi

Symposium 10 9:30 - 11:30 a.m. Ponce de Leon I, II, III (enter left) DIFFERENTIATION PLASTICITY OF STEM CELLS
Organizer: Sean S. Liour, recipient of the 2001 Marian Kies Memorial Award

S10-01 Direct Differentiation of Radial Glial Cells From Embryonic Stem Cells
Liour, S.S., Yu, R.K.

S10-02 Potential of Umbilical Cord Blood Cells For Brain Repair
Sanberg, P.R., Chopp, M., Willing,A.E., Zigova, T., Saporta, S., Song, S., Bickford, P., Garbuzova-Davis, S., Newman, M., Cameron, D.F., Sanchez-Ramos, J.

S10-03 Accessible Stem Cells for the Nervous System
Miller, F.D.

S10-04 Characterization and Potential Therapeutic Uses of Adult Stem Cells from Bone Marrow Stroma
Prockop, D.J.

Symposium 11 9:30 - 11:30 a.m. Ponce de Leon IV (enter center)
BIOLOGY OF PRESENILINS
Organizer: Jorge Busciglio

S11-01 Presenilins as Therapeutic Targets for The Treatment of Alzheimer's Disease
Golde, T.E., Koo, E.D., Weggen, S., Sagi, S.A., Monnier, T., Nyborg, A., Das, P., Jansen, K., Eriksen, J.

S11-02 The Biology of Presenilin and Nicastrin in Drosophila
Fortini, M.E., Hu, Y., Ye, Y., Lukinova, N.I., Seidner, G.

S11-03 Presenilin Complex Form and Function
Fraser, P.E., Yu, G., Chen, F., Arawaka, S., Hasegawa, H., St. George-Hyslop, P.

S11-04 Novel Pathological Mechanisms Involving Presenilin 1 Mutations
Busciglio, J., Pigino, G., Morfini, G., Mattson, M.P.,
Brady, S.T.

Symposium 12 9:30 - 11:30 a.m. Ponce V, VI (enter right)
MOLECULAR INTERVENTION IN SPINAL CORD INJURY AND RECOVERY
Organizers: Regino Perez-Polo and Ian Hendry

S12-01 Inflammatory Responses to Spinal Cord Injury
Perez-Polo, R., Nesic, O., Qiu, J-X., Ye, Z., Svrakic, N., High, K.W., Xu, G-Y., McAdoo, D., Hulsebosch, C.

S12-02 Scar Associated Inhibition of Axon Regeneration: Molecular Inhibitors, Triggers and Treatments
Davies, S.J.A., Tang, Z., Davies, J.E.

S12-03 Cellular Expression of The NG2 Proteoglycan Following Spinal Cord Injury
Grill, R.J.

S12-04 Generation of Cholinergic Neurons From Human Neural Stem Cells
Wu, P., Ye, Y., Tarasenko, Y.

S12-05 Neurotrophic Factor Gene Delivery Supports Axonal Regeneration After Injury
Shine, H.D., Zhou, L., Grider, M.H., McGowen, L.R., Menesses-Diaz, D.A., Zheng, X., Le, W-D., Mamounas, L.

Workshop 12 9:30 - 11:30 a.m. Mediterranean Ballroom
IN VITRO NEUROTOXICOLOGY: TOOLS FOR CELLULAR NEUROBIOLOGY
Organizer Evelyn Tiffany-Castiglioni

W12-01 Effects of Toxicants on Neural Differentiation.
Barone, Jr., S.

W12-02 Cellular Mechanisms of Lead Neurotoxicity
Lasley, S.M.

W12-03 Astroglia as Metal Repositories: Links to Neurodegenerative Diseases
Tiffany-Castiglioni, E.

W12-04 Switching: A Novel Biologically Based Modeling Approach for Risk Assessment of Neurotoxicants."
McMullin, T.

Lunch On Your Own 11:30 a.m. - 1:00 p.m.

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Wednesday afternoon, June 26, 2002

Poster Presentations 1:00 p.m. - 2:30 p.m. Venetian Ballroom
Please dismantle poster by 2:45 p.m.

CP01-01 Dhandapani, K.M., Wade, F.M., De Sevilla, L., Mahesh, V.B., Brann, D.W.
GLOBAL GENE CHIP ANALYSIS OF ESTROGEN AND TAMOXIFEN-REGULATED GENES IN THE RAT CEREBRAL CORTEX

CP02-01 Fernandez, C.I., Cruz, R., Collazo, J., Lopez, O., Bauza, Y., Castellanos, M.R.
COMBINATION OF NGF TREATMENT AND ENRICHMENT ENVIRONMENT IN OLD RATS: BIOCHEMICAL AND BEHAVIIORAL CONSEQUENCES

CP02-02 Simonyi, A., Murch, K., Sun, G.Y.
AGE-RELATED ALTERATIONS OF EXTRACELLULAR SIGNAL-REGULATED KINASE 2 MRNA EXPRESSION IN THE RAT BRAIN

CP03-01 Brunssen, S.H., Houser, E.R, Harry, G.J.
EFFECTS OF EARLY POST-NATAL EXPOSURE OF CEREBRAL CORTEX TO HYPER-IL-6 ON DEVELOPMENT AND COGNITION IN THE CD-1 MOUSE

CP03-02 Levison, S.W., Basu, A., Krady, J.K., O'Malley, M.O., Styren, S.D., DeKosky, S.T.
THE TYPE 1 INTERLEUKIN-RECEPTOR IS ESSENTIAL FOR MULTIPLE ASPECTS OF BRAIN INFLAMMATION

CP03-03 Taiji, M., Tsuchida, A., Nakagawa, T., Ogawa, W., Kasuga, M., Noguchi, H.
ENDROCRINOLOGICAL FUNCTION OF BRAIN-DERIVED NEUROTROPHIC FACTOR IN DIABETIC MICE

CP03-04 Bachis, A., Rabin, S.J., Mocchetti, I.
LIGA20 GANGLIOSIDE PREVENTS EXCITOTOXICITY THROUGH ACTIVATION OF TRKB RECEPTOR

CP03-05 Mocchetti, I., Bachis, A., Rabin, S.J.
GANGLIOSIDES ACTIVATE TRK RECEPTORS BY INDUCING THE RELEASE OF NEUROTROPHINS

CP04-01 Zhou, L., Zheng, X., McGowen, L.R., Baumgartner, B.J., Shine, H.D.
NEUROTROPHIN-3 EXPRESSED IN SITU INDUCES AXONAL REGENERTION IN THE INJURED SPINAL CORD

CP04-02 Grider, M.H., Le, W-D., Mamounas, L.A., Baumgartner, B.J., Zheng, X., Shine, H.D.
ADENOVIRAL-MEDIATED EXPRESSION OF BDNF INDUCES AXONAL REGENERATION AFTER NEUROTOXIC LESION

CP04-03 Sheller, R.A., Schmidt, C.E.
PROTEIN EXPRESSION IN PRIMED PC12 CELLS AFTER ELECTRICAL STIMULATION AND ENHANCED NEURITE OUTGROWTH

CP04-04 Nath, R., DeGuia, F., Akbar, J., Borosky, S.A., Wang, K.K.W.
RHO-ASSOCIATED KINASE (ROCK) INHIBITOR, Y27632, PROMOTES NEURITE OUTGROWTH IN PC12 CELLS IN THE ABSENCE OF NGF

CP05-01 Barbarese, E., Kosturko, L., D'Sa, C., Carson, J.H.
MBP MRNA TRAFFICKING FACTOR HNRNP A2 INTERACTS WITH MICROTUBULES BINDING PROTEIN TOG

CP05-02 Gould, R.M., Bukher, T., Barbarese, E.
EXPRESSION OF RETROGRADE TRANSPORT PROTEINS DURING OLIGODENDROCYTE

CP05-03 Hendry, I.A., Weible, M.W., Ozsarac, N.
DIFFERENCES IN THE RETROGRADE AXONAL TRANSPORT OF NERVE GROWTH FACTOR AND DOPAMINE BETA-HYDROXYLASE

CP05-04 Larocca, J.N., Almazan, G., Rodriguez-Gabin, A.G.
OLIGODENDROCYTE VESICLE TRANSPORT: ROLE OF RAB40C

CP05-05 Lin, M., Brady, S.T.
STUDIES ON TARGETING OF VESICLE TRANSPORT USING VIRALLY MEDICATED EXPRESSION SYSTEM

CP05-06 Morfini, G., Szebenyi, G., Brown, H., Wray, R., Reyna, H., Brady, S.T.
IDENTIFICATION OF A NOVEL PATHWAY FOR THE IN VIVO REGULATION OF FAST ANTEROGRADE AXONAL TRANSPORT

CP05-07 Stokely, M.E., Brady, S.T., Yorio, T.
ENDOTHELIN-B RECEPTOR MEDIATES EFFECT OF INTRAVITREAL ENDOTHELIN ON MITOCHONDRIA-ASSOCIATED ANTEROGRADE AXONAL TRANSPORT

CP06-01 Chou, D.K.H., Schachner, M., Jungalwala, F.B.
GLUCURONYL GLYCOCONJUGATES REPLACE SULFOGLUCURONYL GLYCOCONJUGATES IN HNK-1 KNOCKOUT MICE

CP06-02 Chou, D.K.H., Henion, T.R., Jungalwala, F.B.
HNK-1 CARBOHYDRATE SYNTHESIS IN RETINOIC ACID-INDUCED P19 CELLS

CP07-01 Boldyrev, A.A., Schoner, W.
FUNCTIONAL RELATIONSHIP BETWEEN NA/K-PUMP AND GLUTAMATE RECEPTORS IN CEREBELLUM GRANULE CELLS

CP07-02 Xin, X., Gusheng, W., Zi-Hua, A.F., Ledeen, R.W.
IDENTIFICATION OF A GM1/SODIUM-CALCIUM EXCHANGER COMPLEX IN THE NUCLEAR ENVELOPE OF NON-NEURONAL CELLS

CP08-01 Taglialatela, G., Thomas, M.S., Zhang, W.R., Macdonald, N.J., Andorn, A.C.
SYNERGISTIC MODIFICATION OF INDUCIBLE AND NEURONAL NOS EXPRESSION BY NGF AND TNF ALPHA: RELEVANCE TO CNS AGING

CP09-01 Bichenkov, E., Ellingson, J.S.
PROTEIN KINASE C INHIBITORS COUNTERACT ETHANOL EFFECTS ON MYELIN BASIC PROTEIN EXPRESSION IN CG-4 OLIGODENDROCYTES

CP09-02 Foley, T.D., Kupchak, B.R., Carlson, D.M., Cenera, C.M.
DIFFERENTIAL REGULATION OF BRAIN PROTEIN PHOSPHATASE ACTIVITES BY NITRIC OXIDE AND NITROXYL ANION

CP09-03 Franco, R., Ordaz, B., Pasantes-Morales, H.
HYPOSMOTIC-INDUCED GLUTAMATE RELEASE IN DIFFERENT BRAIN PREPARATIONS: POSSIBLE ROLE OF PKC

CP09-04 Goswami, R., Singh, D., Phillips, G., Kilkus, J., Dawson, G.
MEMBRANE LIPID REGULATION OF THE TUMOR SUPRESSOR PHOSPHATASE PTEN

CP09-05 Mo, L., Neff, N.H., Hadjconstantinou, M.
REGULATION OF JNK SIGNALING PATHWAY BY GM1

CP09-06 Neff, N.H., Duchemin, A.M., Hadjconstantinou, M.
ACTIVATION OF AROMATIC L-AMINO ACID DECARBOXYLASE BY CALCIUM/CALMODULIN KINASE II

CP09-07 Sun, G.Y., Xu, J., Liao, Z., Lo, S-C., Weisman, G.A.
ACTIVATION OF PKC ISOFORMS BY ATP/UTP AND PMA IN MURINE ASTROCYTES

CP10-01 Garcia, M.A., Montecinos, H., Balmaceda-Aguilera, C., Millan, C.,
Nualart, F.
EXPRESSION OF VITAMIN C TRANSPORTER SVCT2 IN HYPOTHALAMIC GLIAL CELLS. AN IMMUNOHISTOCHEMICAL AND KINETIC ANALYSIS

CP10-02 Murphy, E.J.
LORENZO'S OIL, ADRENOLEUKODYSTROPHY, AND THE BLOOD BRAIN BARRIER

CP10-03 Nualart, F., Garcia, M.A., Ulloa, V., Silva, C., Pastor, P., Vera, J.C., Reinicke, K.
HYPOTHALAMIC EPENDYMAL CELLS EXPRESS THE GLUCOSE TRANSPORTER GLUT2, A PROTEIN INVOLVED IN GLUCOSE SENSING

CP11-01 Kolko, M., Rodriguez de Turco, E.B., Diemer, N.H., Bazan, N.G.
SECRETORY PHOSPHOLIPASE A2 SIGNALING PARTLY OVERLAPS GLUTAMATE-MEDIATED EVENTS

CP11-02 Lukiw, W.J., Bazan, N.G.
ALUMINUM TRIGGERS NFKB SIGNALING, INFLAMMATORY AND APOPTOTIC GENE EXPRESSION IN HUMAN NEURAL CELLS

CP11-03 DeCoster, M.A., Bazan, N.G.
GLUTAMATE-MEDIATED CA++ INFLUX AND NUCLEAR DAMAGE IN RETINAL GANGLION CELLS PURIFIED BY PANNING: ROLE OF GLIA

CP11-04 Karageuzyan, K.G., Karagoyozyan, M.K.
ROLE OF MYCOTOXIN ZEARALENON POISONING IN ABNORMALITIES OF THROMBOPLASTIC ACTIVITY IN RATS AND WAYS OF THEIR CORRECTION

CP11-05 Karagyozyan, M.K.
SODIUM THIOSULFATE AS AN EFFECTIVE ANTIOXIDANT SUBSTANCE AT EXPERIMENTAL MYCOTOXIN ZEARALENON POISONING

CP11-06 Boyajyan, A.S., Karagyozyan, M.K.
MACROMOLECULAR COMPLEX FORMATION BETWEEN MYCOTOXIN ZEARALENON AND DOPHAMINE-BETA-MONOOXYGENASE

CP11-07 Blake, A.D.
DIPYRIDAMOLE PROTECTS CULTURED RAT EMBRYONIC CORTICAL NEURONS FROM NEUROTOXIC INSULT

CP11-08 Arutjunyan, A.V., Stepanov, M.G., Kerkeshko, G.O., Prokopenko, V.M., Korenevsky, A.V.
ROLE OF MELATONIN IN AFFECTING DISTRUBANCES OF CENTRAL REGULATION OF REPRODUCTION BY NEUROTOXICANTS

CP11-09 Sabri, M.I., Hashemi, S., Kim, M.S., Spencer, P.S.
AROMATIC HYDROCARBON 1,2-DIACETYLBENZENE CROSS-LINKS NEUROFILAMENT AND OTHER PROTEINS

CP11-10 Lefebvre d'Hellencourt, C., Harry, G.J.
INJURY-INDUCED DIFFERENTIAL GENE EXPRESSION IN LASER CAPTURED HIPPOCAMPAL PYRAMIDAL AND DENTATE GRANULE CELLS

CP11-11 Ali, S.F., Itzhad, Y.
MDMA- AND METH-INDUCED NEUROTOXICITY IN MICE: SENSITIZATION AND DESENSITIZATION TO PSYCHOSTIMULANTS EFFECTS

CP11-12 Sekhon, B.K., Sekhon, C.S., Khan, M., Barbosa, E., Patel, S.J., Singh, I., Singh, A.K.
N-ACETYL CYSTEINE PROTECTS AGAINST INJURY IN ANIMAL MODEL OF TRANSIENT FOCAL CEREBRAL ISCHEMIA

CP11-13 Sur, P., Sribnick, E.A., Wingrave, J.M., Nowak, M.F., Ray, S.K., Banik, N.L.
ESTROGEN ATTENUATES OXIDATIVE STRESS-INDUCED APOPTOSIS IN C6 CELLS

CP11-14 Hazell, A.S., Normandin, L.
UPREGULATION OF "PERIPHERAL-TYPE" BENZODIAZEPINE RECEPTORS IN THE GLOBUS PALLIDUS IN MANGANESE NEUROTOXICITY

CP11-15 Zwingmann, C., Liebfritz, D., Butterworth, R.F.
MECHANISM OF THE PROTECTIVE EFFECT OF HYPOTHERMIA ON AMMONIA TOXICITY IN ASTORCYTES

CP11-16 Dineley, K.E., Richards, L.L., Votyakove, T.V., Reynolds, I.J.
ZINC CAUSES LOSS OF MEMBRANE POTENTIAL AND ALTERS PRODUCTION OF REACTIVE OXYGEN SPECIES IN ISOLATED BRAIN MITOCHONDRIA

CP11-17 McPherson, C.A., Wine, R.N., Kubik, J.A., Harry, G.J.
TRIMETHYLTIN INDUCED HIPPOCAMPAL NEURODEGENERATION ELEVATES CYCLINS A AND B

CP11-18 Choi, S.H., Park, C.H., Seo, J.H., Suh, Y-H.
DEHYDROEVODIAMINE.HCL PROTECTS NEURON FROM CYTOTOXICITY INDUCED BY Ab OR OXIDATIVE STRESS: ITS ANTIOXIDANT

CP12-01 Ellis, R.C., Earnhardt, J.N., Nick, H.S., Hayes, R.L., Anderson, D.K.
CHARACTERIZATION OF CATHEPSIN B EXPRESSION FOLLOWING CONTUSION SPINAL CORD INJURY (SCI)

CP12-02 Earnhardt, J.N., McCray, B., Dobrzoniecka, M., Keeler, B.E., Tabernilla, A.V.C., Nick, H.S., Anderson, D.K.
QUANTITATIVE ASSESSMENT OF GENE EXPRESSION FOLLOWING ACUTE SPINAL CORD INJURY

CP12-03 Banik, N.L., Sribnick, E.A., Wingrave, J.M., Matzelle, D.D., Wilford, G.G., Ray, S.K.
ESTROGEN AS A NEUROPROTECTIVE AGENT IN RAT SPINAL CORD INJURY

CP12-04 Wingrave, J.M., Matzelle, D.D., Wilford, G.G., Hogan, E.L., Banik, N.L.
A STUDY OF JUVENILE RAT SPINAL CORD INJURY

CP12-05 Nesic, O., Svrakic, N.M., Xu, G-Y., McAdoo, D., Westlund, K.N., Hulsebosch, C.E., Perez-Polo, R.J.
INTERLEUKIN 1 DEPENDENT CELL LOSS AFTER SPINAL CORD INJURY (SCI)

CP12-06 Rafati, D.S., Perez-Polo, J.R.
MECHANISMS OF INFLAMMATION IN SPINAL CORD INJURY

CP13-01 Zhang, H., Hu, Y.Y., Murong, S.X.
CHANGES OF BRAIN NITRIC OXIDE PRODUCTION IN EXPERIMENTAL CEREBRAL ISCHEMIA

CP13-02 Zhang, H., Tong, E.T.
NEUROPROTECTION OF MILD HYPOTHERMIA BEGINNING AT DIFFERENT TIME INTERVALS ON CEREBRAL ISCHEMIA/REPERFUSION INJURY

CP13-03 Dhodda, V.K., Sailor, K., Dempsey, R.J., Vemuganti, R.L.R.
NOVEL MEDIATORS OF ISCHEMIC PRECONDITIONING INDUCED NEUROPROTECTION

CP13-04 Foley, T.D., McPherson, D.B., Kilker, R.P.
SUPEROXIDE ACTIVATES SYNAPTIC PARTICULATE NITRIC OXIDE SYNTHASE: IMPLICATIONS FOR SUPEROXIDE SIGNALING AND NEUROTOXICITY

CP13-05 Swanson, R.A., Ying, W., Alano, C.C., Chen, Y.
PARP-1 ACTIVATION CAUSES MITOCHONDRIAL DYSFUNCTION

CP13-06 Maruyama, W., Naoi, M.
ABSTRACT TITLE OXIDATIVE MODIFICATION OF MITOCHONDRIAL PROTEINS AND CELL DEATH IN PARKINSON'S DISEASE

CP13-07 Wang, D.S., Tolentino, P.J., Fan, T., Pike, B.R., Wang, K.K.W., Day, A.L., Hayes, R.L.
INDUCTION OF TISSUE TRANSGLUTAMINSE IN RESPONSE TO IS