| Sunday
June 26th |
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P1
|
Mu-Ming
Poo |
Experience-dependent
Modification of Neural Circuits - Cellular and Molecular Mechanisms |
| |
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S1
|
Molecules
and mechanisms in Schwann cell development - K.R.Jessen & R. Mirsky |
| |
Kristjan
R Jessen |
The function
of Notch and stress kinase signals in early Schwann cell development |
| |
John Svaren |
Krox-20
collaborators and regulation of myelin gene expression" |
| |
R Douglas
Fields |
Purinergic
signaling molecules regulating Schwann cell development in response to impulse
activity in axons |
| |
Nancy Ratner |
Tyrosine
kinase signalling in peripheral nerve tumorigenesis |
| |
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S2
|
Progress
on the pathogenesis of hereditary neurodegenerative disorders - L. Notterpek |
| |
Gopal Thinakaran |
Cell Biology
of Alzheimer's Disease Beta-Amyloid Production. |
| |
David Borchelt |
Transgenic
Mouse Models of Neurodegenerative Disease: Protein Misfolding and Neurodegeneration |
| |
Lawrence
Wrabetz |
Protein
Quality Control of P0 Glycoprotein in Hereditary Neuropathies. |
| |
Lucia Notterpek |
Protein
Aggregation and Aggregate Clearance in PMP22-associated Neuropathies |
| |
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C1
|
Mechanisms
of HIV induced neuropathology: A critical role for astroglia, microglia,
and HIV opiate interactions - P. Knapp |
| |
Avindra
Nath |
Mechanisms
of Neuropathology in HIV: A Clinical Overview |
| |
David Volsky |
HIV alters
astrocyte gene expression and disrupts glutamate homeostasis: parallels
with HIV dementia and HIV brain disease in a mouse model |
| |
Yuri Persidky |
HIV-1 brain
infection, blood-brain barrier (BBB) and co-morbidity factors in HIV-1 associated
neurodegeneration |
| |
Kurt Hauser |
A central
role of astroglia in opioid-mediated neuroplasticity and in the pathology
of drug-HIV interactions |
| |
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C2
|
Mechanisms
and Regulation of Metal Transport into the CNS - J. Connor |
| |
James R.
Connor |
Mechanisms
and Regulation of Iron Transport into the Brain |
| |
Michael
Aschner |
Mechanisms
and Regulation of Manganese Transport into the Brain |
| |
Leah Harris |
Mechanisms
and Regulation of Copper Transport into the Brain |
| |
Michael
Georgieff |
Comparison
of iron transport systems at the intestine, placenta and brain vascular-organ
barriers |
| |
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C3
|
Modeling
Brain Metabolism: Challenges and Controversies - S. Hutson |
| |
Gerald
A. Dienel |
Lactate
muscles its way into consciousness: Influence of brain activation on CMRO2/CMRcarbohydrate
metabolic ratio |
| |
Douglas
Rothman |
Validation
of in vivo measurements of neuronal/astroglial glutamate trafficking |
| |
Kevin Behar |
The Energetics
of Glutamate/Glutamine and GABA/Glutamine Cycling In Vivo |
| |
Rolf Gruetter |
Clairvoyance
and confusion: Outcome and limits of quantitative TCA cycle flux measurements |
| |
K. LaNoue
& S. Huston |
Relationship
between malate/aspartate shuttle and glucose consumption in the mammalian
brain |
| |
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W1
|
In vivo
MR tracking of stem cell transplants in the CNS - J. Bulte |
| |
Jeff WM
Bulte |
Principles
and Methods for the Preparation of Magnetically Labeled Cells |
| |
Tamir Ben-Hur |
MR imaging
of transplanted cell migration in EAE |
| |
Mathias
Hoehn |
Stem cells
for stroke regeneration: an in vivo MRI study |
| |
Christian
Spenger |
Cell tracking
in spinal cord grafts |
| |
Mike Modo |
Visualizing
neural stem cells at work using MRI |
| |
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W2
|
Oligodendrocyte
cell culture models - A. Boullerne & D. Osterhout |
| |
Jean De
Vellis |
How related
are oligodendrocyte cell lines to primary oligodendrocyte cultures? |
| |
Anne Boullerne |
Biology
of adult human oligodendrocytes |
| |
Donna Osterhout |
Molecular
differences between neonatal and adult oligodendrocytes |
| |
Vittorio
Gallo |
Molecular,
functional, and developmental properties of NG2-expressing progenitors in
situ |
| |
Robert
Miller |
Inter-regional
differences of neonatal and adult oligodendrocytes |
| |
Joyce Benjamins
|
Glutamate
receptors in oligodendroglia and their progenitors - good, bad or indifferent? |
| |
|
|
SS1
|
Cutting
Edge Discoveries and Scientific Advances - R. Miskimins |
| |
Georgyi
Los |
The HaloTag:
A Novel Technology for Cellular Analysis |
| |
Gwen Fewell |
Expression
ArrestTM short hairpin RNA libraries: Solutions for transient, stable and
in vivo RNA interference |
| |
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O1
|
Neurotoxicology
- R. Wiggins & N. Banik |
| |
Bennett,
K. |
Estrogen
treatment and immunoselection of basal forebrain cholinergic neurons |
| |
Adibhatla,
R.M. |
Cytokines,
Lipid Metabolism, and CDP-choline in Stroke |
| |
Rama Rao,
K.V. |
Manganese-induced
astrocyte swelling: role for the low grade brain edema in chronic hepatic
encephalopathy |
| |
Jeitner,
T.M. |
Hydrogen
sulfide as a scavenger of HOCl |
| |
Madrigal,
J.M. |
Neuroprotection
by noradrenaline; Effects on neuronal IkB-alpha and PPAR receptors |
| |
Mongin,
A.A. |
Comparison
of Pharmacological Profiles of Volume-Regulated Cl- Currents and Excitatory
Amino Acid Release in Cultured Astrocytes |
| |
Samantaray,
S. |
Presence
of MPP+ and motoneuron apoptosis with calpain activation in spinal
cord of mice with MPTP-induced parkinsonism |
| |
|
|
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PF1
|
Public
Forum: Focus on Autism: M. Carson |
| |
Carlos
A. Pardo, MD |
Is there
brain inflammation in Autism? |
| |
Lisa Boulanger, Ph.D. |
Immune proteins in normal brain development and plasticity: possible implications for autism |
| |
|
Panel Discussion and audience questions |
| |
|
|
| Monday
June 27th |
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|
P2
|
Mary
Hatten |
New Directions
in CNS Neuronal Migration
|
| |
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S3
|
Wiring
the nervous system - M. Fox |
| |
Peter Scheiffele |
Molecular
mechanisms of synaptic differentiation |
| |
Akira Chiba |
Dendrite
guidance |
| |
Hisashi
Umemori |
FGFs are
presynaptic organizing molecules in the mammalian brain |
| |
Alex Schier
|
TBA |
| |
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|
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|
S4
|
Frontiers
in Embryonic Stem Cell Research - O. Brüstle & S. Zhang |
| |
James Thomson |
Human embryonic
stem cells: Derivation and differentiation |
| |
Woo Suk
Hwang |
Cloning
of human ES cells |
| |
Ron McKay |
The molecular
biology of CNS stem cells |
| |
Su-Chun
Zhang |
Neural
differentiation of ES cells |
| |
Oliver
Brüstle |
From ES
cells to functional neurons and glia |
| |
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C4
|
Toll-like
Receptors in the Nervous System - G. Konat |
| |
Tammy Kielian |
Differential
roles for TLR2 in CNS bacterial infection and glial |
| |
Ian Marriott |
Astrocytes
as sentinel cells for CNS pathogens" |
| |
Kalipada
Pahan |
Role of
Toll-like receptors in microglial activation" |
| |
Gregory
Konat |
Double
stranded RNA triggers proinflammatory response in astrocytes: Implications
for MS etiology" |
| |
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C5
|
Beyond
Immune Privilege: Is the CNS an immunologically active organ? - B. Melchior |
| |
Steve Miller |
CNS dendritic
cells drive naïve T cell proliferation and epitope spreading in relapsing
EAE |
| |
Zsu Zsu
Zabry |
Dendritic
cells and the initiation of immunity in the CNS |
| |
Francesca
Aloisi |
Formation
of ectopic lymphoid tissue in the inflamed brain |
| |
Monica
Carson |
The healthy
CNS actively regulates and redirects autoreactive T cell responses towards
protective effector functions |
| |
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|
C6
|
Ependymal
Cells: Physiology, Pathology, and Neurochemistry - B. Hamprecht |
| |
Stephan
Verleysdonk |
Functional
neurochemistry of cultured ependymal cells |
| |
Bradley
K.Yoder |
Hydrocephalus
in a murine intraflagellar transport mutant |
| |
Pedro Fernandez-Llebrez |
Specialized
ependyma: subcommissural organ and adult germinative zones |
| |
Conrad
E. Johanson |
Putative
linkage of fibroblast growth factor 2 with vasopressin in brain fluid homeostasis:
Role of the choroid plexus |
| |
Francisco
Nualart |
Vitamin
C transporters in ependymal cells |
| |
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|
C7
|
The
Cell Biology of Myelin Repair - R. Franklin |
| |
Robin Franklin |
Introduction:
new themes in CNS remyelination |
| |
Jeff Mason |
IGF-1 protects
oligodendrocytes and prevents the formation of chronically demyelinated
lesions |
| |
Patrizia
Casaccia-Bonnefil |
Histone
deacetylase activity in oligodendrocytes: development and repair |
| |
Brahim
Nait-Oumesmar |
Forced
expression of OLIG transcription factors promotes neural stem cells derived
oligodendrocytes for myelin repair |
| |
Fraser
Sim |
Fate-regulating
pathways in adult human oligodendrocyte progenitors |
| |
Regina
Armstrong |
Oligodendrocyte
regeneration and remyelination after chronic demyelination |
| |
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|
W4
|
Glycogen:
a static or dynamic energy source - M. McKenna & A. Schousboe |
| |
Bruce Ransom |
Role of
glycogen in supporting axonal energy metabolism |
| |
Ray Swanson |
Manipulation
of brain glycogen levels in vivo: effects on neuron function and survival
during severe hypoglycemia. |
| |
Helle Waagepetersen |
Role of
glycogen in neurotransmission |
| |
Gerry Dienel |
Glycogenolysis
may reveal a large, "hidden cost" of astrocytic work |
| |
Rolf Gruetter |
In vivo
studies of glycogen: turnover vs. net changes |
| |
Leif Hertz |
Inhibition
of glycogenolysis at specific time points abolishes learning in day-old
chick |
| |
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|
W3
|
Promoting
Research Integrity: Do we need better scientists or better science? - R.
DeVries |
| |
Raymond
De Vries |
Discussion
of recent NIH funded study on research integrity. |
| |
Nick Steneck
|
Office
of Research Integrity of the Department of Health and Human Services |
| |
Leo T.
Furcht |
Vice President
for Science Policy, The Federation of American Societies for Experimental
Biology |
| |
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O2
|
Oligodendrocytes:
Life, Death, and Resurrection M. Gardinier and P. Wight |
| |
Lang, J.K.
|
BMP Regulation
of Adult Human Oligodendrocyte Progenitor Fate |
| |
McLaughlin,
M. |
Dynamics
and cellular transport of PLP is altered in the rumpshaker mutant |
| |
Shankar,
S.L. |
Gas6/Axl
signaling protects oligodendrocytes from TNF-induced apoptosis via the PI3
kinase/Akt survival pathway |
| |
Skundric,
D.S. |
Neutralization
of IL-16 reduces inflammation, demyelination, axonal damage, and reverses
paralysis during relapsing-remitting EAE |
| |
Grinspan,
J.B. |
Induction
of bone morphogenetic proteins in mouse spinal cord during experimental
autoimmune encephalomyelitis |
| |
Fressinaud,
C. |
NT-3 and
PDGF partially restore mature oligodendrocyte plasticity after multiple
insults in vitro |
| |
Gao, L.M.
|
Specification
of optic nerve oligodendrocyte precursors by retinal ganglion cell axons.
|
| |
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|
|
| Tuesday
June 28th |
|
|
|
P3
|
Klaus
Nave |
Axon-glia
interactions and the control of myelination
|
| |
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|
S5
|
Minocycline
Therapy for CNS Disorders: Cellular and Molecular Aspects - I. Duncan |
| |
Robert
M. Friedlander |
Mechanisms
of minocycline-mediated neuroprotection. |
| |
Jari Koistinaho |
Novel therapeutic
targets on minocycline in the brain. |
| |
V. Wee
Yong |
The promise
of minocycline in neurology. |
| |
Maria Nikodemova |
Molecular
mechanisms of minocycline anti-inflammatory effects. |
| |
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|
S6
|
Astrocytic
regulation of neuronal excitability and synaptic transmission - P. Haydon |
| |
Vladimir
Parpura |
Exocytotic
release of glutamate from astrocytes |
| |
Ken McCarthy |
Glial calcium
signaling modulates hippocampal synaptic transmission |
| |
Giorgio
Carmignoto |
Neuronal
synchrony in the hippocampus mediated by glutamate released from astrocytes |
| |
Phil Haydon |
Astrocyte
regulation of synaptic transmission and plasticity |
| |
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|
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|
C8
|
Fast
axonal transport, neurofilament phosphorylation and synaptiic transmission
- R. Gould |
| |
Harish
Pant |
Why cytoskeletal
proteins are selectively phosphorylated in the axonal and not the cell body
compartment? |
| |
Scott Brady |
Regulation
of Fast Axonal Transport and Neurodegeneration |
| |
George
Augustine |
Molecular
mechanisms of synaptic vesicle exocytosis |
| |
Eileen
Lafer |
Molecular
Mechanisms of Synaptic Vesicle Endocytosis |
| |
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C9
|
Therapeutic
manipulation of CNS inflammation/immune responses in Alzheimer's disease
- M. Carson |
| |
Gary Landreth |
Nuclear receptors as therapeutic targets in CNS inflammatory indications |
| |
David Morgan |
Microglial activation in APP transgenic mice after passive immunization with anti-Abeta antibodies |
| |
Benoit Melchior |
TREM-mediated activation of microglia and macrophages: implications for vaccine mediated Alzheimer's disease therapies |
| |
David Cribbs |
Immunotherapy
for Alzheimer’s disease |
| |
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|
C10
|
The
Role of Adult Derived Stem Cells in the Nervous System - R.I. Cohen |
| |
Rick I.
Cohen |
Introduction
to adult stem cells |
| |
Eva Mezey |
Can bone
marrow cells help heal the brain? |
| |
Terry Burns
|
MAPCs and
neurogenic potential. |
| |
Jeffery
D. Kocsis |
Marrow
stromal cell transplantation to repair of the injured nervous system |
| |
Fred Jerrold
Roisen |
Human adult
olfactory epithelial derived neural progenitors a possible source of progenitors
for autologous transplantation |
| |
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C11
|
Lipid
Pathways as targets for MS Therapy - K. Chandross & J. Merrill |
| |
Klaus Nave |
The role
of cholesterol in myelin assembly |
| |
Doug Feinstein |
Potential
use of PPAR Agonists for Treatment of Demyelinating Disease |
| |
Karen Chandross |
Selective
Agonists Activate PPAR-delta Signaling Complexes and Promote the Differentiation
of Oligodendrocyte Progenitors. |
| |
Inderjit
Singh |
Statins
in MS Inflammatory Disease |
| |
|
|
|
| Wednesday
June 29th |
|
|
|
P4
|
Stuart
Lipton |
Paradigm
Shift in Neuroprotective Drug Treatment |
| |
|
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|
|
S7
|
NF-kappa
B in Neurons: Smoking the Red Herrings - S. Barger |
| |
Paul Massa |
Unique
control of NF-kappaB activation by canonical and translational pathways
in neurons" |
| |
Steve Barger |
Abortive
activation of NF-kappaB in neurons: Is there any other kind?" |
| |
John Bethea |
Identification
of Novel Regulators of NF-kB activation |
| |
David Park |
The dual
nature of NFkappaB in neuronal death/survival" |
| |
|
|
|
|
S8
|
Mechanisms
of Axonal Degeneration in Myelin Diseases - B. Trapp |
| |
Peter Stys |
Excited
White Matter: Glutamate and Axonal Injury |
| |
Kenneth
Smith |
A Strategy
for Axonal Protection in Inflammatory Demyelinating Disease |
| |
Joel Black |
Na Channels
and Axonal Degeneration in MS and its models |
| |
Bruce Trapp |
Mitochrondrial
Dysfunction and Axonal Degeneration in Chronic MS Patients |
| |
|
|
|
|
C12
|
Transcriptional
mechanisms of Cerebral Inflammation - R. Vemuganti |
| |
Midori
Yenari |
Influence
of hypothermia on post-ischemic inflammation: role of NF-kB |
| |
Tiina Kauppinen |
PARP-1
activation in post-ischemic inflammation and neuronal death |
| |
Paul Drew |
Role of
PPAR-gamma in cerebral inflammation |
| |
Raghu Vemuganti |
Role of
STAT-SOCS signaling in controlling stroke-induced inflammation and brain
damage |
| |
Anthony
J. Williams |
Neuroprotection
with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation
to NF-kB, inflammatory gene expression, and leukocyte infiltration |
| |
|
|
|
|
C13
|
Neural
progenitors of the subventricular zone and their role in pathology and repair
- V. Gallo |
| |
Fiona Doetsch |
Neural
Stem Cells of the Adult SVZ and their Developmental Regulation |
| |
Vittorio
Gallo |
NG2-expressing
Progenitors of the Perinatal SVZ Generate Inhibitory Interneurons in the
Hippocampus and Olfactory Bulb |
| |
Ann Baron-Van
Evercoren |
Migration
and multipotentiality of PSA-NCAM Neural Precursors in the Developing Brain |
| |
Steve Levison |
Regenerative
Responses of Resident Neural Stem Cells to Developmental Brain Injuries |
| |
|
|
|
|
C14
|
Integrin/ECM
signalling and neural development - C. ffrench-Constant |
| |
Holly Colognato
|
Integrin/growth
factor interactions in myelination. |
| |
Uli Mueller |
Integrin
function in CNS development |
| |
Bruce Patton |
Laminins
in peripheral nerve development |
| |
David Calderwood |
Integrin
activation - a final common pathway |
| |
Charles
ffrench-Constant |
Introduction
- emerging roles for ECM in neural development |
| |
|
|
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|
W5
|
Ammonia
neurotoxicity: Molecular mechanisms and protection - J. Albrecht |
| |
Michael
D. Norenberg |
Role of
glutamine in the mechanism of ammonia neurotoxicity. |
| |
Roger F.
Butterworth |
Energy
failure and cerebral edema in hyperammonemia: roles of glutamine, lactate
and alanine |
| |
Vicente
Felipo |
Role of
altered NMDA receptor signal transduction in acute ammonia toxicity and
in neurological deficits in chronic hyperammonemia |
| |
Jan Albrecht |
Endogenous
neuroprotectants in ammonia neurotoxicity |
| |
Magdalena
Zielinska |
Ammonia
affects the nitric oxide-cGMP pathway in cultured rat astrocytes and cerebral
capillary endothelial cells |
| |
Regina
Rodrigo |
Differential
alterations of the glutamate-nitric oxide-cGMP pathway in cerebellum and
cerebral cortex in hepatic failure |
| |
|
|
|
|
W6
|
Zebrafish
as a model for nervous system development and disease - S. Moorman |
| |
Stephen
Moorman |
Zebrafish
as a model organism |
| |
Mary Halloran |
Studying
axon guidance in the zebrafish |
| |
Stephen
Ekker |
Targeted
gene knockdown in zebrafish |
| |
Hans-Martin
Pogoda |
Genomic
approaches to studying myelination in zebrafish |
| |
|
|
|
O3
|
Glia
and Neurological Disorders - R. Swanson and M. Brenner |
| |
Westmark,
C. |
FMRP Mediates
mGluR1-Activated Translation of Amyloid Precursor Protein |
| |
Dello Russo,
C. |
A new HSP90
inhibitor reduces experimental autoimmune encephalomyelitis |
| |
Li, J.
|
Nrf2-dependent
ARE activation is a gain of function alteration specific to differentiated
astrocytes |
| |
Jana, A.
|
HIV-1
neurotoxic proteins and activated astroglia kill human primary neurons via
neutral sphingomyelinase |
| |
Carpentier,
P.A |
The role
of protein kinase R in the activation of astrocytes by viral infection |
| |
Yamada,
M. |
BMP signaling
regulates glial scarring |
| |
Brambilla,
R |
Inhibition
of astroglial NF-kB reduces inflammation and improves functional recovery
following spinal cord injury |
| |
|
|
|
O4
|
Intracellular
signaling in Glia and Neurons A. Gow and B. Fuss |
| |
Saha, R.N.
|
Greater
availability of NF-kB p65:p50 in glia than neurons: Implications for neurodegenerative
disorders |
| |
Lin, W. |
ER Stress
Modulates the Response of Myelinating Oligodendrocytes to the Immune Cytokine
Interferon-gamma |
| |
Marta,
C.B. |
Elucidating
the Mechanism of anti-MOG Antibody-Mediated Demyelination |
| |
Zhang,
Z. |
Activation
of the Caspase Independent Pathway in PLP Overexpresser Mice |
| |
Morfini,
G. |
Molecular
Mechanisms Underlying Kinesin Inhibition by Polyglutamine-expanded proteins
|
| |
Hynds,
D.L. |
Inhibition
of RhoA Signaling Decreases Actin Filament Content in Neuroblastoma Growth
Cones |
