Presidential Lectures
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How to specify and modulate the neurotransmitter inventory of an entire nervous system Oliver Hobart, PhD |
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Signaling pathways regulating oligodendrocyte differentiation Basic Neurochemistry Lecture Wendy Macklin, PhD |
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Controlling the sorting and diffusion of membrane components: Involvement in neuronal polarity Bettina Winckler, PhD |
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A novel miokine protects the brain in Alzheimer models Sergio Ferreira, PhD |
Sessions & Colloquia
*Eastern Standard Time*
MONDAY
10:00 - 11:00 AM
PS-01 Poster Session 1
11:00 AM - 12:00 PM
PRES-01 How to specify and modulate the neurotransmitter inventory of an entire nervous system
Oliver Hobart, PhD
12:30 PM - 2:30 PM
S-01 Protein homeostasis regulation in neurodegeneration
Chair: Reut Shalgi
Adapting protein homeostasis to ameliorate degenerative diseases - Jeff Kelly
Chaperone network perturbations modulate neurodegeneration-related protein aggregation - Reut Shalgi
Amyloid disassembly by the action of molecular chaperones - Bernd Bukau
Understanding proteostasis disfunction and aggregate management in neurodegenerative disease - Judith Frydman
S-02 Recent advances in brain lipid research in health and diseases
Chairs: Xianlin Han & Eric Murphy
Lipid binding proteins and brain fatty acid uptake and metabolism: What is the role of liver-fatty - Eric Murphy
Yin-Yang mechanisms regulating lipid peroxidation of docosahexaenoic acid and arachidonic acid - Grace Sun
Lipidomic analysis of post-mortem Alzheimer’s disease pre-frontal cortex reveals lipid changes - Ameer Taha
Sulfatide loss and inflammation - Xianlin Han
3:00 PM - 5:00 PM
S-02 The central role of glia in regulating responses to CNS infection
Chair: Tammy Kielan
Glial cells and their role in host defense following coronavirus infection of the CNS - Thomas Lane
Staphylococcus aureus Craniotomy Infections Alter Glial Responsiveness - Tammy Kielian
Defense of the Brain by Microglia and Other CNS Myeloid Cells - Dorian McGavern
The Multi-faceted Role of Glia in the Parasitized Brain - Emma Wilson
S-04 Molecular mechanisms underlying heterogeneity in depression Marian Kies session
Chair: Fernanda Neutzling Kaufmann
Stress-induced vascular changes driving depression vs stress resilience - Caroline Menard
Sex specific immune mechanisms of depression: Translating therapeutic targets - Georgia Hodes
Could stressing our gut microbes makes us depressed? - Marie-Claude Audet
5:30 PM - 7:00 PM
C-01 Astrocyte-Neuron Interaction in Health and Disease
Chairs: Margaret Ho & Vladimir Parpura
Vesicular Glutamate Release from Astrocytes at the Interface of Signaling and Metabolism - Vladimir Parpura
Striatal astrocytes: identity, form and function - Xinzhu Yu
Glial Autophagy in Parkinson's Disease - Margaret Ho
The guiding role of GFAP in astrocytic plasticity in rat hypothalamic neuroendocrine regulation - Yufeng Wang
C-02 Lipid metabolism: Regulation of Myelination in Health and Disease
Chairs: Haesun Kim & Judith Grinspan
Lipid signaling regulates CNS myelination through the sterol regulatory element binding protein - Judith Grinspan
Insights into Adrenoleukodystrophy and Peroxisomal Metabolism on CNS Myelination from Zebrafish Mode - Quentin Raas
Cholesterol trafficking within Schwann cells with or without PMP22 - Lucia Notterpek
TUESDAY
10:00 - 11:00 AM
PS-02 Poster Session 2
11:00 AM - 12:00 PM
PRES-02 Signaling pathways regulating oligodendrocyte differentiation
Wendy Macklin, PhD *Basic Neurochemistry Lecture*
12:30 PM - 2:30 PM
S-05 Glia cells in neuronal circuitry function: does sex matter?
Chairs: Babette Fuss & Pamela Knapp
Critical Roles for Microglia During Critical Periods of Brain Development - Margaret McCarthy
Sexual dimorphism of dark microglia: consequences on neuronal circuits - Marie-Eve Tremblay
Sex differences in HIV-related neurocognitive and motoric disorders - Pamela Knapp
Glutamate transporters as regulators of CNS myelination - Babette Fuss
S-06 Epigenetic approaches in addiction research: Interrogation of molecular mechanisms and potential treatment strategies
Chairs: Jean Lud Cadet & Subramaniam Jayanthi
Compulsive methamphetamine taking and abstinence in the presence of adverse consequences: epigenetic - Jean Lud Cadet
Role of DNA hydroxymethylation in methamphetamine addiction - Subramaniam Jayanthi
Not all stimulant drugs are the same: insights from histone acetylation and deacetylation in the pre - Veronica Bisagno
Methamphetamine self-administration under punishment is associated with selective activation of NGF- Oscar Torres
3:00 PM - 5:00 PM
S-07 Iron Metabolism in the CNS: Implications for neurodegenerative and demyelinating diseases
Chairs: Juana Pasquini & Pablo Paez
The Role of Ferritin and Sema4A in Oligodendrocyte health and disease - James Connor
Managing Brain Iron at the Blood Brain Barrier - Daniel Kosman
The Function of DMT1 Ferritin and Transferrin Receptor in Myelination and Remyelination - Juana Pasquini
Cellular respiration and iron deficiency: taking a deep breath - Pablo Paez
S-08 Glial Chloride Channels and Transporters: At the Intersection of Cell Volume and Brain Health
Chairs: Alexander Mongin & Corinne Wilson
The cross talk between MLC1, GlialCAM and the glial chloride channels ClC-2 and LRRC8 in leukodystrophies - Raul Estevez
NKCC1 chloride transporter in white matter injury - Dandan Sun
Glutamate-releasing LRRC8A/SWELL1 channel in astrocytes modulates synaptic transmission and promotes stroke damage - Zhaozhu Qiu
Functional heterogeneity and pathological roles for heteromeric LRRC8 channels in the CNS - Corinne Wilson
5:30 PM - 7:00 PM
C-03 Astroglial Metabolism and the Brain Noradrenergic System
Chairs: Robert Zorec & Nina Vardjan
Noradrenergic regulation of glial activation: Relevance to AD and MS? - Douglas Feinstein
Astrocytes integrate local sensory and brain-wide neuromodulatory signals in the mouse visual cortex - Matthew Holt
Astroglial metabolic excitability mediated by lactate and noradrenaline - Nina Vardjan
Astroglial lactate in health and disease - Pierre Magiestretti
C-04 Microglia-neuron Interactions in Health and Disease
Chairs: Long-Jun Wu & Lindsay De Biase
Midbrain microglia: unique cell phenotypes and their impact on neuronal health and function - Lindsay De Biase
Microglia regulate synaptic formation, neuronal activity, and local synchronization - Junichi Nabekura
Elucidating niche-associated functions of retinal microglia - Daniel Saban
Neuronal activity controls microglial process dynamics in awake mice - Long-Jun Wu
OR-01 Oral Presentations 1
WEDNESDAY
10:00 - 11:00 AM
PS-03 Poster Session 3
11:00 AM - 12:00 PM
PRES-03 Controlling the sorting and diffusion of membrane components: Involvement in neuronal polarity
Bettina Winckler, PhD
12:30 PM - 2:30 PM
S-09 Star of the Show: Astrocytes take center stage in controlling neural circuit formation
Chair: Michael Fox
Retinal inputs signal astrocytes to recruit interneurons into the developing visual thalamus - Michael Fox
Astrocytes mediate cell-type-specific synaptic organization - Denise Garcia
Astrocytes and dendritic development - Michelle Olsen
TBA - Iryna Ethell
S-10 Novel non-narcotic strategies for pain management
Chair: Daniela Salvemini
Highly selective A3 adenosine receptor agonists as non-narcotic analgesics for neuropathic pain states - Daniela Salvemini
Unlocking NaV1.7’s pain potential: discovery and initial characterization of a novel class of non-narcotic compounds selectively targeting NaV1.7 through inhibition of a protein-protein interaction - Rajesh Khanna
Disruption of protein-protein interactions downstream of NMDA receptors as a non-narcotic, non-addicting analgesic strategy - Andrea Hohmann
Blocking S1PR1 prevent opioid-induced adverse effects - Timothy Doyle
3:00 PM - 5:00 PM
S-11 Mechanisms of white matter injury and repair after traumatic brain injuries
Chairs: Steven Levison & Regina Armstrong
Axon-Myelin Protection and Plasticity in Traumatic White Matter Injury - Regina Armstrong
Repair and Restoration of the Cerebrovasculature Following TBI: Therapeutic Implications - Andre Obenaus
TBI-induced Intracellular Signaling and Myelin Disruption in Oligodendrocytes - Haesun Kim
Neuroregenerative and Protective Functions of LIF after Pediatric Concussion” - Steven Levison
S-12 Therapeutic Potential of Psychedelics and Related Molecules Jordi Folch-Pi 2020 Session
Chair: David E. Olsen
TBD - Robert Malenka
TBD - Boris Heifets
Imaging the rapid and long-lasting actions of psychoactive drugs: from ketamine to psilocybin - Alex Kwan
TBD - David E. Olsen
5:30 PM - 7:00 PM
C-05 A closer look: Inherited versus Acquired disorders of Myelin
Chair: Akshata Almad
Modeling and Therapy for Pelizaeus-Merzbacher Disease - Paul Tesar
Cortical remyelination in an acquired model of myelin loss - Jennifer Orthmann-Murphy
Modeling of TUBB4A associated Leukodystrophy - Akshata Almad
C-06 Leukocyte Trafficking to the Inflamed CNS: Chemokines and Integrins
Chairs: Sarah Lutz & Thomas Lane
Blood-brain barrier permeability: a sneak attack through caveolae - Sarah Lutz
Innate immune responses and their role in defense and disease following viral infection of the CNS - Thomas Lane
Blockade of CXCR2 promotes the recruitment of a reparative myeloid subset to the inflamed CNS - Ben Segal
CNS access of regulatory immune cells is controlled by integrins - Estelle Bettelli
C-07 CRMPs in the CNS: Novel roles in health and disease
Chairs: Douglas Feinstein & Rajesh Khanna
Defining the CaV2.2-CRMP2 molecular interaction identifies a first-in-class small molecule anti-nociceptive - Rajesh Khanna
Targeting CRMP2-CLN6 complex in Batten Disease - Jill Weimer
Neuroprotection and repair in EAE by antagonizing NgR-dependent CRMP2 phosphorylation - Steven Petratos
THURSDAY
11:00 AM - 12:00 PM
PRES-04 A novel miokine protects the brain in Alzheimer models
Sergio Ferreira, PhD
12:30 PM - 2:30 PM
S-13 Extracellular Vesicles in Alzheimer’s Disease
Chairs: Erhard Bieberich & Guanghu Wang
Interactions of microglial-derived microvesicles and amyloid-beta - Michael Nichols
Plasma Extracellular Vesicles Enriched for Neuronal and Astrocytic Origin in Alzheimer’s Disease - Dimitrios Kapogiannis
Function of Ceramide Transport Protein for Extracellular Vesicles in Alzheimer’s Disease - Pilar Martinez-Martinez
Abeta-associated exosomes from astrocytes drive amyloid pathology in Alzheimer’s disease - Erhard Bieberich
S-14 Unconventional Roles for Astrocytes in Disease
Chairs: Jessica Williams & Brian Daniels
Disease-relevant differences between human and mouse astrocytes - Ye Zhang
Protective roles for astrocytic cell death signaling during CNS viral infection - Brian Daniels
The astrocyte immunoproteasome mediates protection during chronic CNS autoimmunity - Jessica Williams
Astrocytes rescue dying neurons during stroke - Kazuhide Hayakawa
3:00 PM - 5:00 PM
S-15 Small molecule approaches to understanding and treating neurological disease Jordi Folch-Pi 2019 Session
Chair: Drew Adams
Accumulation of 8,9-unsaturated sterols as a unifying mechanism for drug-induced remyelination - Drew Adams
Chemistry-based methods for identifying binding sites for steroid modulators of ion channels - Doug Covey
Allosteric regulation of a protein quality control E3 ligase - Matt Scaglione
Targeting glial biology to promote remyelination in neurodegenerative diseases - Tracy Yuen Hugenberger
S-16 Enteric nervous system remodeling
Chair: Malvyne Rolli-Derkinderen
The enteric nervous system in gut homeostasis - Meenakshi Rao
Enteric Glial cells at center stage of digestive diseases - Malvyne Rolli-Derkinderen
Enteric Glia activity and gliotransmission in health and disease - Vladimir Grubisic
5:30 PM - 7:00 PM
OR-02 Oral Presentations 2
OR-03 Oral Presentations 3
OR-04 Oral Presentations 4
