ASN * American Society for Neurochemistry
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Presidential Lectures

HobartOliver

How to specify and modulate the neurotransmitter inventory of an entire nervous system

Oliver Hobart, PhD

MacklinWendy

Signaling pathways regulating oligodendrocyte differentiation

Basic Neurochemistry Lecture

Wendy Macklin, PhD

WincklerBettina

Controlling the sorting and diffusion of membrane components: Involvement in neuronal polarity

Bettina Winckler, PhD

FerreiraSergio

A novel miokine protects the brain in Alzheimer models

Sergio Ferreira, PhD

Sessions & Colloquia

*Eastern Standard Time*

MONDAY

10:00 - 11:00 AM

PS-01 Poster Session 1

11:00 AM - 12:00 PM

PRES-01 How to specify and modulate the neurotransmitter inventory of an entire nervous system

Oliver Hobart, PhD

12:30 PM - 2:30 PM

S-01     Protein homeostasis regulation in neurodegeneration
Chair: Reut Shalgi
Adapting protein homeostasis to ameliorate degenerative diseases - Jeff Kelly
Chaperone network perturbations modulate neurodegeneration-related protein aggregation - Reut Shalgi
Amyloid disassembly by the action of molecular chaperones - Bernd Bukau
Understanding proteostasis disfunction and aggregate management in neurodegenerative disease - Judith Frydman

S-02     Recent advances in brain lipid research in health and diseases
Chairs: Xianlin Han & Eric Murphy
Lipid binding proteins and brain fatty acid uptake and metabolism: What is the role of liver-fatty - Eric Murphy
Yin-Yang mechanisms regulating lipid peroxidation of docosahexaenoic acid and arachidonic acid - Grace Sun
Lipidomic analysis of post-mortem Alzheimer’s disease pre-frontal cortex reveals lipid changes - Ameer Taha
Sulfatide loss and inflammation - Xianlin Han

3:00 PM - 5:00 PM

S-02     The central role of glia in regulating responses to CNS infection
Chair: Tammy Kielan
Glial cells and their role in host defense following coronavirus infection of the CNS - Thomas Lane
Staphylococcus aureus Craniotomy Infections Alter Glial Responsiveness - Tammy Kielian
Defense of the Brain by Microglia and Other CNS Myeloid Cells - Dorian McGavern
The Multi-faceted Role of Glia in the Parasitized Brain - Emma Wilson

S-04    Molecular mechanisms underlying heterogeneity in depression  Marian Kies session
Chair: Fernanda Neutzling Kaufmann
Stress-induced vascular changes driving depression vs stress resilience - Caroline Menard
Sex specific immune mechanisms of depression: Translating therapeutic targets - Georgia Hodes
Could stressing our gut microbes makes us depressed? - Marie-Claude Audet

5:30 PM - 7:00 PM

C-01     Astrocyte-Neuron Interaction in Health and Disease
Chairs: Margaret Ho & Vladimir Parpura
Vesicular Glutamate Release from Astrocytes at the Interface of Signaling and Metabolism - Vladimir Parpura
Striatal astrocytes: identity, form and function - Xinzhu Yu
Glial Autophagy in Parkinson's Disease - Margaret Ho
The guiding role of GFAP in astrocytic plasticity in rat hypothalamic neuroendocrine regulation - Yufeng Wang 

C-02     Lipid metabolism: Regulation of Myelination in Health and Disease
Chairs: Haesun Kim & Judith Grinspan
Lipid signaling regulates CNS myelination through the sterol regulatory element binding protein - Judith Grinspan
Insights into Adrenoleukodystrophy and Peroxisomal Metabolism on CNS Myelination from Zebrafish Mode - Quentin Raas
Cholesterol trafficking within Schwann cells with or without PMP22 - Lucia Notterpek

TUESDAY

10:00 - 11:00 AM

PS-02 Poster Session 2

11:00 AM - 12:00 PM

PRES-02 Signaling pathways regulating oligodendrocyte differentiation

Wendy Macklin, PhD   *Basic Neurochemistry Lecture*

12:30 PM - 2:30 PM

S-05    Glia cells in neuronal circuitry function: does sex matter?
Chairs: Babette Fuss & Pamela Knapp
Critical Roles for Microglia During Critical Periods of Brain Development - Margaret McCarthy
Sexual dimorphism of dark microglia: consequences on neuronal circuits - Marie-Eve Tremblay
Sex differences in HIV-related neurocognitive and motoric disorders - Pamela Knapp
Glutamate transporters as regulators of CNS myelination - Babette Fuss 

S-06    Epigenetic approaches in addiction research: Interrogation of molecular mechanisms and potential treatment strategies
Chairs: Jean Lud Cadet & Subramaniam Jayanthi
Compulsive methamphetamine taking and abstinence in the presence of adverse consequences: epigenetic - Jean Lud Cadet
Role of DNA hydroxymethylation in methamphetamine addiction - Subramaniam Jayanthi
Not all stimulant drugs are the same: insights from histone acetylation and deacetylation in the pre - Veronica Bisagno
Methamphetamine self-administration under punishment is associated with selective activation of NGF- Oscar Torres

3:00 PM - 5:00 PM

S-07    Iron Metabolism in the CNS: Implications for neurodegenerative and demyelinating diseases
Chairs: Juana Pasquini & Pablo Paez
The Role of Ferritin and Sema4A in Oligodendrocyte health and disease - James Connor
Managing Brain Iron at the Blood Brain Barrier - Daniel Kosman
The Function of DMT1 Ferritin and Transferrin Receptor in Myelination and Remyelination - Juana Pasquini
Cellular respiration and iron deficiency: taking a deep breath - Pablo Paez

S-08    Glial Chloride Channels and Transporters: At the Intersection of Cell Volume and Brain Health
Chairs: Alexander Mongin & Corinne Wilson
The cross talk between MLC1, GlialCAM and the glial chloride channels ClC-2 and LRRC8 in leukodystrophies - Raul Estevez
NKCC1 chloride transporter in white matter injury - Dandan Sun
Glutamate-releasing LRRC8A/SWELL1 channel in astrocytes modulates synaptic transmission and promotes stroke damage - Zhaozhu Qiu
Functional heterogeneity and pathological roles for heteromeric LRRC8 channels in the CNS - Corinne Wilson

5:30 PM - 7:00 PM

C-03     Astroglial Metabolism and the Brain Noradrenergic System
Chairs: Robert Zorec & Nina Vardjan
Noradrenergic regulation of glial activation: Relevance to AD and MS? - Douglas Feinstein
Astrocytes integrate local sensory and brain-wide neuromodulatory signals in the mouse visual cortex - Matthew Holt
Astroglial metabolic excitability mediated by lactate and noradrenaline - Nina Vardjan
Astroglial lactate in health and disease - Pierre Magiestretti

C-04     Microglia-neuron Interactions in Health and Disease
Chairs: Long-Jun Wu & Lindsay De Biase
Midbrain microglia: unique cell phenotypes and their impact on neuronal health and function - Lindsay De Biase
Microglia regulate synaptic formation, neuronal activity, and local synchronization - Junichi Nabekura
Elucidating niche-associated functions of retinal microglia - Daniel Saban
Neuronal activity controls microglial process dynamics in awake mice - Long-Jun Wu

OR-01     Oral Presentations 1

WEDNESDAY

10:00 - 11:00 AM

PS-03 Poster Session 3

11:00 AM - 12:00 PM

PRES-03 Controlling the sorting and diffusion of membrane components: Involvement in neuronal polarity

Bettina Winckler, PhD

12:30 PM - 2:30 PM

S-09    Star of the Show: Astrocytes take center stage in controlling neural circuit formation
Chair: Michael Fox
Retinal inputs signal astrocytes to recruit interneurons into the developing visual thalamus - Michael Fox
Astrocytes mediate cell-type-specific synaptic organization - Denise Garcia
Astrocytes and dendritic development - Michelle Olsen
TBA - Iryna Ethell

S-10     Novel non-narcotic strategies for pain management
Chair: Daniela Salvemini
Highly selective A3 adenosine receptor agonists as non-narcotic analgesics for neuropathic pain states - Daniela Salvemini
Unlocking NaV1.7’s pain potential: discovery and initial characterization of a novel class of non-narcotic compounds selectively targeting NaV1.7 through inhibition of a protein-protein interaction - Rajesh Khanna
Disruption of protein-protein interactions downstream of NMDA receptors as a non-narcotic, non-addicting analgesic strategy - Andrea Hohmann
Blocking S1PR1 prevent opioid-induced adverse effects - Timothy Doyle

3:00 PM - 5:00 PM

S-11     Mechanisms of white matter injury and repair after traumatic brain injuries
Chairs: Steven Levison & Regina Armstrong
Axon-Myelin Protection and Plasticity in Traumatic White Matter Injury - Regina Armstrong
Repair and Restoration of the Cerebrovasculature Following TBI: Therapeutic Implications - Andre Obenaus
TBI-induced Intracellular Signaling and Myelin Disruption in Oligodendrocytes - Haesun Kim
Neuroregenerative and Protective Functions of LIF after Pediatric Concussion” - Steven Levison

S-12   Therapeutic Potential of Psychedelics and Related Molecules   Jordi Folch-Pi 2020 Session

Chair: David E. Olsen
TBD - Robert Malenka
TBD - Boris Heifets
Imaging the rapid and long-lasting actions of psychoactive drugs: from ketamine to psilocybin - Alex Kwan
TBD - David E. Olsen

5:30 PM - 7:00 PM

C-05     A closer look: Inherited versus Acquired disorders of Myelin
Chair: Akshata Almad
Modeling and Therapy for Pelizaeus-Merzbacher Disease - Paul Tesar
Cortical remyelination in an acquired model of myelin loss - Jennifer Orthmann-Murphy
Modeling of TUBB4A associated Leukodystrophy - Akshata Almad

C-06     Leukocyte Trafficking to the Inflamed CNS: Chemokines and Integrins
Chairs: Sarah Lutz & Thomas Lane
Blood-brain barrier permeability: a sneak attack through caveolae - Sarah Lutz
Innate immune responses and their role in defense and disease following viral infection of the CNS - Thomas Lane
Blockade of CXCR2 promotes the recruitment of a reparative myeloid subset to the inflamed CNS - Ben Segal
CNS access of regulatory immune cells is controlled by integrins - Estelle Bettelli

C-07     CRMPs in the CNS: Novel roles in health and disease
Chairs: Douglas Feinstein & Rajesh Khanna
Defining the CaV2.2-CRMP2 molecular interaction identifies a first-in-class small molecule anti-nociceptive - Rajesh Khanna
Targeting CRMP2-CLN6 complex in Batten Disease - Jill Weimer
Neuroprotection and repair in EAE by antagonizing NgR-dependent CRMP2 phosphorylation - Steven Petratos

THURSDAY

11:00 AM - 12:00 PM

PRES-04 A novel miokine protects the brain in Alzheimer models

Sergio Ferreira, PhD

12:30 PM - 2:30 PM

S-13     Extracellular Vesicles in Alzheimer’s Disease
Chairs: Erhard Bieberich & Guanghu Wang
Interactions of microglial-derived microvesicles and amyloid-beta - Michael Nichols
Plasma Extracellular Vesicles Enriched for Neuronal and Astrocytic Origin in Alzheimer’s Disease - Dimitrios Kapogiannis
Function of Ceramide Transport Protein for Extracellular Vesicles in Alzheimer’s Disease - Pilar Martinez-Martinez
Abeta-associated exosomes from astrocytes drive amyloid pathology in Alzheimer’s disease - Erhard Bieberich

S-14     Unconventional Roles for Astrocytes in Disease
Chairs: Jessica Williams & Brian Daniels
Disease-relevant differences between human and mouse astrocytes - Ye Zhang
Protective roles for astrocytic cell death signaling during CNS viral infection - Brian Daniels
The astrocyte immunoproteasome mediates protection during chronic CNS autoimmunity - Jessica Williams
Astrocytes rescue dying neurons during stroke - Kazuhide Hayakawa

3:00 PM - 5:00 PM

S-15     Small molecule approaches to understanding and treating neurological disease Jordi Folch-Pi 2019 Session
Chair: Drew Adams
Accumulation of 8,9-unsaturated sterols as a unifying mechanism for drug-induced remyelination - Drew Adams
Chemistry-based methods for identifying binding sites for steroid modulators of ion channels - Doug Covey
Allosteric regulation of a protein quality control E3 ligase - Matt Scaglione
Targeting glial biology to promote remyelination in neurodegenerative diseases - Tracy Yuen Hugenberger

S-16     Enteric nervous system remodeling
Chair: Malvyne Rolli-Derkinderen
The enteric nervous system in gut homeostasis - Meenakshi Rao
Enteric Glial cells at center stage of digestive diseases - Malvyne Rolli-Derkinderen
Enteric Glia activity and gliotransmission in health and disease - Vladimir Grubisic

5:30 PM - 7:00 PM

OR-02   Oral Presentations 2

OR-03   Oral Presentations 3

OR-04   Oral Presentations 4